Sofenib 200 mg (Tablet)
Unit Price: ৳ 300.00 (3 x 4: ৳ 3,600.00)
Strip Price: ৳ 1,200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sorafenib tosylate |
| Company | Renata limited |
Indications
- Treatment of unresectable hepatocellular carcinoma (HCC)
- Treatment of advanced renal cell carcinoma (RCC)
Pharmacology
- Kinase inhibitor
- Decreases tumor cell proliferation
- Inhibits multiple intracellular and cell surface kinases
- Involvement in tumor cell signaling, angiogenesis, and apoptosis
- Inhibition of tumor growth and angiogenesis
Dosage & Administration
- Recommended daily dose of 400 mg tablets taken twice daily
- Administration without food
- Treatment continuation until clinical benefit ceases or toxicity occurs
- Temporary interruption and dose reduction for adverse reactions
- Missed dose instructions
Interaction
- Contraindications with specific anticancer drug combinations
- Potential interaction with various substrates and enzymes
Contraindications
- Known severe hypersensitivity
- Contraindication in certain lung cancer cases
Side Effects
- Cardiac ischemia
- Infarction
- Hemorrhage
- Hypertension
- Hand-foot skin reaction
- Gastrointestinal perforation
- Wound healing complications
Pregnancy & Lactation
- Potential fetal harm
- Advice for women of childbearing potential
Precautions & Warnings
- Risk of cardiac ischemia and infarction
- Increased risk of bleeding
- Risk of hypertension
- Dermatologic toxicities
- Gastrointestinal perforation
- Warfarin co-administration
- Wound healing complications
- Use in specific lung cancer cases
- Interactions with UGT1A1 substrates
- Interactions with Docetaxel & Doxorubicin
- Hepatic impairment effects
- Neomycin co-administration effects
Use in Special Populations
- Pediatric use not studied
- No differences in safety or efficacy between older and younger patients
- No dose adjustment for renal impairment
- AUC reduction in mild to moderate hepatic impairment
Overdose Effects
- No specific treatment
- Adverse reactions observed at high doses
Therapeutic Class
- Targeted Cancer Therapy
Storage Conditions
- Room temperature storage below 30°C
- Dispensing in original bottle