Acin 75 mg/5 ml (Syrup)

100 ml bottle: ৳ 45.30

Medicine Details

Category Details
Generic Ranitidine hydrochloride
Company Biopharma limited
Also available as

Indications

  • Treatment of active duodenal ulcer
  • Benign gastric ulcer
  • Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent
  • Post operative stress ulcer
  • Zollinger-Ellison Syndrome
  • Gastroesophageal reflux disease (GERD)
  • Gastro-intestinal haemorrhage from stress ulcer in seriously ill patient
  • Recurrent haemorrhage in patients with bleeding peptic ulcer
  • Before general anesthesia in patient considered to be at risk of acid aspiration
  • Preventative measure in obstetric patients

Pharmacology

  • Competitive blocking of histamine at H2-receptors
  • Inhibition of gastric acid secretion
  • No effect on pepsin secretion
  • No effect on pentagastrin-stimulated intrinsic factor secretion
  • No effect on serum gastrin

Dosage & Administration

  • 150 mg tablet twice daily for active duodenal ulcer
  • 300 mg tablet daily at night for 4 to 8 weeks for active duodenal ulcer
  • 150 mg tablet twice daily for reflux oesophagitis
  • 300 mg tablet daily at bedtime for up to 8 weeks for reflux oesophagitis
  • 150 mg tablet 3 times daily for Zollinger-Ellison syndrome
  • 150 mg tablet twice daily for episodic dyspepsia
  • 300 mg tablet at bedtime for up to 6 weeks for episodic dyspepsia
  • 150 mg tablet at night for prevention of recurrences
  • Oral dose of 2-4 mg/kg twice daily for children with peptic ulcer
  • Intravenous injection every six to eight hours for haemorrhage from stress ulceration in seriously ill patients
  • Intravenous infusion at a rate of 25 mg per hour for two hours for haemorrhage prophylaxis
  • Intramuscular injection every six to eight hours for haemorrhage prophylaxis
  • Intramuscular or slow intravenous injection 45 to 60 minutes before general anesthesia in at-risk patients
  • Oral dose of 2 mg/kg to 4 mg/kg twice daily for children with peptic ulcer

Interaction

  • Delayed absorption and increased peak serum concentration with propantheline bromide
  • Minimal inhibition of hepatic metabolism of certain drugs
  • Alteration of absorption of pH-dependent drugs
  • Reduced bioavailability with antacids

Contraindications

  • Hypersensitivity to Ranitidine

Side Effects

  • Altered bowel habit
  • Dizziness
  • Rash
  • Tiredness
  • Reversible confusional states
  • Headache
  • Decreased blood counts
  • Muscle or joint pain

Pregnancy & Lactation

  • Transplacental crossing
  • Use only if essential during pregnancy
  • Excretion in human breast milk
  • Caution during nursing

Precautions & Warnings

  • Reduced dosage for patients with impaired renal function
  • Reduced dosage for patients with impaired hepatic function

Use in Special Populations

  • Similar ulcer healing rates in elderly patients
  • Similar adverse effects incidence in elderly patients

Overdose Effects

  • Specific action minimizes problems from overdosage
  • Symptomatic and supportive therapy recommended

Therapeutic Class

  • H2 receptor antagonist

Reconstitution

  • Various dilution recommendations for IV administration

Storage Conditions

  • Store in a cool and dry place
  • Protect from light

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