Amuran 150 mg (Tablet)
Unit Price: ৳ 2.00 (100's pack: ৳ 200.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Amulet pharmaceuticals ltd |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Post-operative stress ulcer
- Zollinger-Ellison syndrome
- Gastroesophageal reflux disease (GERD)
- Treatment of gastrointestinal hemorrhage from stress ulcer in seriously ill patients
- Recurrent hemorrhage in patients with bleeding peptic ulcer
- Prevention of acid aspiration before general anesthesia, particularly in obstetric patients
Pharmacology
- Competitively blocks histamine at H2-receptors of gastric parietal cells
- Inhibits gastric acid secretion
- Does not affect pepsin secretion
- Does not affect pentagastrin-stimulated intrinsic factor secretion or serum gastrin
Dosage administration
- Usual dosage of 150 mg twice daily for 4 to 8 weeks for duodenal and gastric ulcers
- Dosage of 150 mg twice daily for reflux esophagitis
- Increased dosage for Zollinger-Ellison syndrome
- Dosage of 150 mg twice daily for episodic dyspepsia
- Maintenance dosage of 150 mg at night for preventing recurrences
- Recommended dosage for peptic ulcer in children: 2-4 mg/kg twice daily, maximum 300 mg daily
Interaction
- Delayed absorption and increased peak serum concentration with propantheline bromide
- Minimal inhibition of hepatic metabolism of coumarin anticoagulants, theophylline, diazepam, and propranolol
- May alter absorption of pH-dependent drugs
- May reduce bioavailability with antacids
Contraindications
- Hypersensitivity to ranitidine
Side effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy lactation
- Crosses the placenta
- Caution during lactation
Precautions warnings
- Reduced dosage for patients with impaired renal and hepatic function
Use special populations
- Similar ulcer healing rates in elderly patients as in younger patients
- No difference in the incidence of adverse effects in elderly patients
Overdose effects
- Specific in action with no particular problems expected following overdosage
- Symptomatic and supportive therapy recommended
- Potential removal from plasma by hemodialysis if required
Therapeutic class
- H2 receptor antagonist
Reconstitution
- Dilution for slow IV injection
- Dilution for intermittent slow IV infusion
- Dilution for continuous IV infusion
- Special dilution for patients with hypersecretory conditions
Storage conditions
- Store in a cool and dry place
- Protect from light