Antac 150 mg (Tablet)
Unit Price: ৳ 1.81 (100's pack: ৳ 181.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Ambee pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Post operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal haemorrhage from stress ulcer in seriously ill patient
- Recurrent haemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patient considered to be at risk of acid aspiration particularly obstetric patients
Pharmacology
- Competitively blocks histamine at H2-receptors
- Inhibits gastric acid secretion
- Does not affect pepsin secretion, pentagastrin-stimulated intrinsic factor secretion or serum gastrin
Dosage & Administration
- Usual dosage is 150 mg twice daily for 4 to 8 weeks for duodenal and gastric ulcer treatment
- Usual dosage is 150 mg twice daily for up to 8 weeks for reflux oesophagitis
- 150 mg 3 times daily and increased if necessary up to 6 g daily in divided doses for Zollinger Ellison syndrome
- Usual dosage is 150 mg twice daily for up to 6 weeks for episodic dyspepsia
- Maintenance dosage of 150 mg at night for preventing recurrences
- Recommended oral dose for children (peptic ulcer) is 2-4 mg/kg twice daily, maximum 300 mg daily
- Ranitidine injection may be given intravenously or intramuscularly at specific doses
Interaction
- Delayed absorption and increased peak serum concentration with propantheline bromide
- Minimally inhibits hepatic metabolism of certain drugs
- May alter absorption of pH-dependent drugs
- May reduce bioavailability with antacids
Contraindications
- Patients hypersensitive to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Ranitidine crosses the placenta
- No evidence of impaired fertility or harm to the fetus
- Caution should be exercised when administered to a nursing mother
Precautions & Warnings
- Should be given in reduced dosage to patients with impaired renal and hepatic function
Use in Special Populations
- Ulcer healing rates have been found similar in elderly patients
- No difference in the incidence of adverse effects between elderly and younger patients
Overdose Effects
- No particular problems are expected
- Symptomatic and supportive therapy should be given
- Drug may be removed from the plasma by haemodialysis if required
Therapeutic Class
- H2 receptor antagonist
Reconstitution
- Specific reconstitution guidelines for slow IV injection, intermittent slow IV infusion, continuous IV infusion, and Zollinger-Ellison syndrome treatment
Storage Conditions
- Store in a cool and dry place
- Protect from light