Asinar 150 mg (Tablet)
Unit Price: ৳ 2.51 (10 x 10: ৳ 251.00)
Strip Price: ৳ 25.10
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Synovia pharma plc |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Postoperative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastrointestinal hemorrhage from stress ulcer in seriously ill patients
- Recurrent hemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patients considered to be at risk of acid aspiration, particularly obstetric patients
Pharmacology
- Competitively blocks histamine at H2-receptors of the gastric parietal cells
- Inhibits gastric acid secretion
- Does not affect pepsin secretion
- Does not affect pentagastrin-stimulated intrinsic factor secretion
- Does not affect serum gastrin
Dosage & Administration
- Usual dosage is 150 mg twice daily taken in the morning and evening or 300 mg as a single daily dose at night for 4 to 8 weeks for duodenal and gastric ulcer
- Dosage of 150 mg twice daily or 300 mg at bedtime for up to 8 weeks for reflux esophagitis
- Dosage of 150 mg 3 times daily and increased if necessary up to 6 g daily in divided doses for Zollinger-Ellison syndrome
- Dosage for episodic dyspepsia is 150 mg twice daily or 300 mg at bedtime for up to 6 weeks
- Maintenance dose of 150 mg at night for preventing recurrences
- For children with peptic ulcer: 2-4 mg/kg twice daily, maximum 300 mg daily
- Ranitidine injection may be given either as a slow (over a period of at least two minutes) intravenous injection of 50 mg, after dilution to a volume of 20 ml per 50 mg dose, which may be repeated every six to eight hours
- Continuous intravenous infusion of 150 mg diluted in 250 mL of dextrose 5% inj or NaCl 0.9%, lactated Ringer's, Na bicarbonate 5% solution for patients with Zollinger-Ellison syndrome or other hypersecretory conditions
Interaction
- Delayed absorption and increased peak serum concentration with propantheline bromide
- Minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam, and propranolol
- May alter absorption of pH-dependent drugs (e.g. ketoconazole, midazolam, glipizide)
- May reduce bioavailability with antacids
Contraindications
- Patients hypersensitive to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Ranitidine crosses the placenta
- No evidence of impaired fertility or harm to the fetus due to Ranitidine
- Use during pregnancy only if considered essential
- Ranitidine is excreted in human breast milk
- Caution should be exercised when administered to a nursing mother
Precautions & Warnings
- Should be given in reduced dosage to patients with impaired renal and hepatic function
Use in Special Populations
- Ulcer healing rates found similar in patients age 65 and over with those in younger patients
- No difference in the incidence of adverse effects in elderly patients
Overdose Effects
- Specific in action and no particular problems are expected following overdosage
- Symptomatic and supportive therapy should be given as appropriate
- If required, the drug may be removed from the plasma by hemodialysis
Therapeutic Class
- H2 receptor antagonist
Reconstitution
- Asinar 50 mg diluted to a concentration ≤2.5 mg/mL with NaCl 0.9% injection or dextrose 5% or 10%, lactated Ringer's, Na bicarbonate 5% solution for slow IV injection
- Asinar 50 mg diluted to a concentration ≤0.5 mg/mL of dextrose 5% injection or NaCl 0.9%, lactated Ringer's, Na bicarbonate 5% solution for intermittent slow IV infusion
- For patients with Zollinger-Ellison syndrome or other hypersecretory conditions: Asinar should be diluted to a concentration ≤2.5 mg/mL with dextrose 5% or NaCl 0.9%, lactated Ringer's, Na bicarbonate 5% solution
Storage Conditions
- Store in a cool and dry place
- Protect from light