Astac 150 mg (Tablet)
Unit Price: ৳ 2.00 (10 x 10: ৳ 200.00)
Strip Price: ৳ 20.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Astra biopharmaceuticals ltd |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Post operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal haemorrhage from stress ulcer in seriously ill patient
- Recurrent haemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patient considered to be at risk of acid aspiration particulary
- Obstetric patients
Pharmacology
- Competitively blocks histamine at H2-receptors
- Inhibits gastric acid secretion
- Does not affect pepsin secretion
- Pentagastrin-stimulated intrinsic factor secretion or serum gastrin
Dosage & Administration
- Usual dosage is 150 mg twice daily for 4 to 8 weeks
- Reflux oesophagitis dosage: 150 mg twice daily or 300 mg at bedtime for up to 8 weeks
- Zollinger Ellison syndrome dosage: 150 mg 3 times daily
- Episodic dyspepsia dosage: 150 mg twice daily or 300 mg at bedtime for up to 6 weeks
- Maintenance dosage: 150 mg at night for preventing recurrences
Interactions
- Delayed absorption and increased peak serum concentration with propantheline bromide
- Minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam and propanolol
- May alter absorption of pH-dependent drugs
- May reduce bioavailability with antacids
Contraindications
- Patients hypersensitive to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Ranitidine crosses the placenta
- Should only be used during pregnancy if considered essential
- Excreted in human breast milk
Precautions & Warnings
- Should be given in reduced dosage to patients with impaired renal and hepatic function
Use in Special Populations
- Ulcer healing rates found similar in patients age 65 and over
- No difference in the incidence of adverse effects
Overdose Effects
- No particular problems expected following overdosage with the drug
- Symptomatic and supportive therapy should be given as appropriate
- Drug may be removed from the plasma by haemodiaiysis
Therapeutic Class
- H2 receptor antagonist
Reconstitution
- Astac 50 mg diluted to a concentration ≤2.5 mg/mL with NaCl 0.9% inj or dextrose 5% or 10%, lactated Ringer's, Na bicarbonate 5% soln
- Astac 150 mg diluted in 250 mL of dextrose 5% inj or NaCl 0.9%, lactated Ringer's, Na bicarbonate 5% soln
Storage Conditions
- Store in a cool and dry place
- Protect from light