Muterol 5 mg/5 ml (Oral Solution)

60 ml bottle: ৳ 20.13

Medicine Details

Category	Details
Generic	Bambuterol hydrochloride
Company	Acme laboratories ltd
Also available as	Muterol 10 mg tablet Muterol 20 mg tablet

Indications

Bronchial asthma
Chronic bronchitis
Emphysema
Other lung diseases where bronchospasm is a complicating factor

Pharmacology

Bambuterol is a prodrug of terbutaline, a long-acting β2 adrenergic receptor agonist used in the treatment of asthma. It predominantly stimulates β2 receptors, producing relaxation of bronchial smooth muscle, inhibition of release of endogenous spasmogens, inhibition of edema caused by endogenous mediators, and increased mucociliary clearance.

Dosage & Administration

Children 2-5 years: 10 mg (10 ml syrup)
Children 6-12 years: 10 mg (10 ml syrup), may be increased to 20 mg
Adult: Recommended initial dose 10 mg, may be increased to 20 mg after 1-2 weeks depending on clinical effect

Interaction

Succinylcholin
MAOIs (monoamine oxidase inhibitors)
β2-blockers
Corticosteroids
Diuretics
Muscle relaxants
Sympathomimetic xanthine derivatives

Contraindications

Hepatic impairment, liver cirrhosis, severely impaired liver function

Side Effects

Fatigue
Nausea
Palpitation
Headache
Dizziness
Tremor

Pregnancy & Lactation

Caution recommended during first trimester of pregnancy. Caution recommended if administered to breastfeeding patients due to potential passage into breast milk. Terbutalin passes into breast milk but is unlikely to influence the child with therapeutic doses. Transient hypoglycemia reported in newborn pre-term infants after maternal β2 agonist treatment.

Precautions & Warnings

Dose should be reduced in patients with severely impaired renal function, genetic deficiencies of plasma cholinesterase, severe ischemic heart disease

Overdose Effects

No reported case of bambuterol overdosage. Overdosing may result in high levels of terbutaline and similar symptoms, including headache, anxiety, tremor, nausea, tonic muscle cramps, palpitations, tachycardia, cardiac arrhythmias, fall in blood pressure, hyperglycemia, and lactacidosis may occur. High doses may cause hypokalemia due to potassium redistribution.