Denitine 150 mg (Tablet)
Unit Price: ৳ 2.00 (100's pack: ৳ 200.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Doctors chemical works ltd |
Title
- Denitine Tablet & Syrup
Categories
- Gastrointestinal Medication
- Ulcer Treatment
- Acid Reducer
- Reflux Relief
Description
- Denitine is indicated for the treatment of active duodenal ulcer, benign gastric ulcer, ulcer associated with non-steroidal anti-inflammatory agents, post-operative stress ulcer, Zollinger-Ellison Syndrome, GERD, gastrointestinal hemorrhage, recurrent hemorrhage, and prevention of acid aspiration before general anesthesia.
DosageForm
- Tablet
- Syrup
- IV Injection
- IV Infusion
DosageAdministration
- Usual dosage for duodenal and gastric ulcer is 150 mg twice daily for 4 to 8 weeks
- For reflux esophagitis: 150 mg twice daily for up to 8 weeks
- For Zollinger Ellison syndrome: 150 mg 3 times daily, increased if necessary
- Episodic dyspepsia: 150 mg twice daily for up to 6 weeks
- Maintenance: 150 mg at night for preventing recurrences
- For children (peptic ulcer): 2-4 mg/kg twice daily, maximum 300 mg daily
- IV Injection & IV Infusion: Specific dosages based on condition and patient type
Pharmacology
- Competitively blocks histamine at H2-receptors of the gastric parietal cells which inhibits gastric acid secretion
- Does not affect pepsin secretion, pentagastrin-stimulated intrinsic factor secretion or serum gastrin
Interaction
- Delayed absorption and increased peak serum concentration with propantheline bromide
- Minimally inhibits hepatic metabolism of certain drugs
- May alter absorption of pH-dependent drugs, reduce bioavailability with antacids
Contraindications
- Hypersensitivity to Ranitidine
SideEffects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
PregnancyLactation
- Crosses placenta with no evidence of impaired fertility or harm to the fetus
- Excreted in human breast milk, caution advised during lactation
SpecialPopulation
- Reduced dosage for patients with impaired renal and hepatic function
- Similar ulcer healing rates in elderly patients as in younger patients
Overdose
- Specific in action, no particular problems expected following overdosage
- Symptomatic and supportive therapy recommended if overdosage occurs
- Haemodialysis may be used if necessary
TherapeuticClass
- H2 Receptor Antagonist
Reconstitution
- Specific reconstitution guidelines for slow IV injection, intermittent slow IV infusion, and continuous IV infusion
StorageConditions
- Store in a cool and dry place, protect from light