Dugal 150 mg (Tablet)
Unit Price: ৳ 0.77 (150's pack: ৳ 115.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Reman drug laboratories ltd |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Ulcer associated with non-steroidal anti-inflammatory agent
- Post operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal hemorrhage from stress ulcer in seriously ill patient
- Recurrent hemorrhage in patients with bleeding peptic ulcer
- Prevention of acid aspiration in obstetric patients
Pharmacology
- Competitively blocks histamine at H2-receptors
- Inhibits gastric acid secretion
- Does not affect pepsin secretion
- Does not affect pentagastrin-stimulated intrinsic factor secretion
- Does not affect serum gastrin
Dosage & Administration
- Usual dosage for duodenal and gastric ulcer: 150 mg twice daily or 300 mg as a single daily dose
- Dosage for reflux oesophagitis: 150 mg twice daily or 300 mg at bedtime
- Dosage for Zollinger-Ellison syndrome: 150 mg 3 times daily, increased if necessary
- Dosage for maintenance: 150 mg at night
- Dosage for children with peptic ulcer: 2-4 mg/kg twice daily, maximum 300 mg daily
- Dosage for Ranitidine IV injection & IV Infusion
Interaction
- Delayed absorption and increased peak serum concentration with propantheline bromide
- Minimally inhibits hepatic metabolism of certain drugs
- May alter absorption of pH-dependent drugs
- May reduce bioavailability with antacids
Contraindications
- Hypersensitivity to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Crosses placenta
- Excreted in human breast milk
- Caution during lactation
Precautions & Warnings
- Reduced dosage for patients with impaired renal and hepatic function
Use in Special Populations
- Similar ulcer healing rates in elderly patients
- No difference in adverse effects incidence in elderly patients
Overdose Effects
- No particular problems expected following overdosage
- Symptomatic and supportive therapy as appropriate
Therapeutic Class
- H2 receptor antagonist
Reconstitution
- Instructions for slow IV inj
- Instructions for intermittent slow IV infusion
- Instructions for continuous IV infusion
- Instructions for patients with hypersecretory conditions
Storage Conditions
- Store in a cool and dry place
- Protect from light