Duran 75 mg/5 ml (Syrup)

100 ml bottle: ৳ 45.00

Medicine Details

Title and Categories

  • Duran Tablet
  • Medicine
  • Healthcare Product
  • Gastric Ulcer Treatment
  • Acid Reducer
  • H2 Receptor Antagonist

Indications

  • Treatment of active duodenal ulcer
  • Treatment of benign gastric ulcer
  • Treatment and prevention of ulcer associated with non-steroidal anti-inflammatory agent
  • Post operative stress ulcer treatment
  • Zollinger-Ellison Syndrome treatment
  • Gastroesophageal reflux disease (GERD) treatment
  • Gastrointestinal haemorrhage from stress ulcer in seriously ill patient treatment
  • Recurrent haemorrhage in patients with bleeding peptic ulcer treatment
  • Prevention of acid aspiration before general anesthesia
  • Treatment of episodic dyspepsia

Mode of Action

Competitively blocks histamine at H2-receptors of the gastric parietal cells inhibiting gastric acid secretion

Pharmacology

Does not affect pepsin secretion, pentagastrin-stimulated intrinsic factor secretion or serum gastrin

Dosage and Administration

  • Usual 150 mg dosage twice daily for 4 to 8 weeks for duodenal and gastric ulcer
  • 150 mg twice daily or 300 mg at bedtime for reflux esophagitis
  • 150 mg 3 times daily for Zollinger-Ellison Syndrome
  • 150 mg twice daily for episodic dyspepsia

Interaction

  • Delayed absorption and increased peak serum concentration with propantheline bromide
  • Minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam, and propranolol
  • May alter absorption of pH-dependent drugs like ketoconazole, midazolam, and glipizide
  • May reduce bioavailability with antacids

Contraindications

Hypersensitivity to Ranitidine

Side Effects

  • Altered bowel habit
  • Dizziness
  • Rash
  • Tiredness
  • Reversible confusional states
  • Headache
  • Decreased blood counts
  • Muscle or joint pain

Pregnancy and Lactation

  • Crosses the placenta
  • Caution advised during lactation

Precautions and Warnings

Reduced dosage for patients with impaired renal and hepatic function

Use in Special Populations

Similar ulcer healing rates in elderly patients

Overdose Effects

No particular problems expected, symptomatic and supportive therapy recommended

Therapeutic Class

H2 receptor antagonist

Reconstitution

  • Dilution instructions for different administration methods

Storage Conditions

Store in a cool and dry place, protect from light

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