Voricon 50 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Voriconazole |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Invasive aspergillosis
- Candidemia (nonneutropenic) and disseminated candidiasis
- Esophageal candidiasis
- Serious infections caused by Scedosporium apiospermum and Fusarium Species
- Patients intolerant of, or refractory to other therapy
Pharmacology
Voriconazole is a triazole antifungal medication that inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-alpha sterol demethylase, resulting in a depletion of ergosterol in fungal cell membrane
Dosage & Administration
- Oral tablet and powder for suspension to be taken at least one hour before or one hour following a meal
- Loading/maintenance dose regimen based on body weight for oral intake and specific fungal infections for injection
- Dosage varies for different fungal infections
Interaction
- Requires dosage adjustment and monitoring when co-administered with CYP3A4, CYP2C9, and CYP2C19 inhibitors and inducers
- May increase concentrations and activity of drugs that are CYP3A4, CYP2C9, and CYP2C19 substrates, necessitating dose reduction and adverse reaction monitoring
- Requires increased maintenance oral and intravenous dosage with co-administration of specific drugs
Contraindications
- Known hypersensitivity to Voriconazole or any other components of this drug
- Co-administration with specific drugs due to risk of serious adverse reactions or loss of efficacy
Side Effects
- Abdominal pain
- Anemia
- Blurred vision
- Headache
- Chest pain
- Nausea
- Diarrhea
Pregnancy & Lactation
No adequate and well-controlled studies in pregnant women; use during pregnancy only if potential benefit justifies potential risk to the fetus
Precautions & Warnings
Long-term exposure (>180 days) requires careful assessment of benefit-risk balance; association with squamous cell carcinoma of the skin reported
Use in Special Populations
Efficacy not established for children under 12 years of age
Overdose Effects
No specific data found about overdose of Voricon
Therapeutic Class
Other Antifungal preparations
Reconstitution
Instructions for suspension reconstitution; store reconstituted suspension between 15°C-30°C; discard after 14 days
Storage Conditions
Keep out of reach of children; store in a dry place below 25°C and protected from light; store Voricon powder for suspension between 2°C to 8°C