Duran 50 mg/100 ml (IV Infusion)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Techno drugs ltd |
| Also available as |
Title
Duran
Categories
- Medicine
- Gastrointestinal
Description
Ranitidine competitively blocks histamine at H2-receptors of the gastric parietal cells, inhibits gastric acid secretion, and is indicated in the treatment of active duodenal ulcer, benign gastric ulcer, ulcer associated with non-steroidal anti-inflammatory agent, Zollinger-Ellison Syndrome, GERD, and more.
DosageInstructions
150 mg twice daily taken in the morning and evening or 300 mg as a single daily dose at night for 4 to 8 weeks for duodenal and gastric ulcer. Different dosage for other conditions.
ModeOfAction
Competitively blocks histamine at H2-receptors of the gastric parietal cells, inhibiting gastric acid secretion without affecting pepsin secretion, pentagastrin-stimulated intrinsic factor secretion, or serum gastrin.
Interaction
Delayed absorption and increased peak serum concentration with propantheline bromide. Minimally inhibits hepatic metabolism of certain drugs. May alter absorption of pH-dependent drugs and reduce bioavailability with antacids.
Contraindications
- Hypersensitivity to Ranitidine
SideEffects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
PregnancyAndLactation
Crosses the placenta with no evidence of impaired fertility or harm to the fetus. Excreted in human breast milk.
PrecautionsAndWarnings
Should be given in reduced dosage to patients with impaired renal and hepatic function.
UseInSpecialPopulations
Ulcer healing rates found similar in elderly patients with no difference in adverse effects.
OverdoseEffects
No particular problems expected following overdosage. Symptomatic and supportive therapy should be given as appropriate.
TherapeuticClass
H2 receptor antagonist
Reconstitution
Duran 50 mg diluted to specific concentrations for slow IV injection, intermittent slow IV infusion, and continuous IV infusion. Specific dilution for patients with hypersecretory conditions.
StorageConditions
Store in a cool and dry place. Protect from light.