Doctrim 800 mg+160 mg (Tablet)

Title

Cotrimoxazole Tablet

Categories

• Medicine
• Antibiotic
• Antimicrobial

Description

Cotrimoxazole is a bactericidal medication with broad-spectrum activity against various bacterial infections. It consists of a combination of Trimethoprim and Sulphamethoxazole and is used to treat respiratory tract infections, genito-urinary tract infections, gastro-intestinal tract infections, and more. It is important to consider contraindications, side effects, dosage, storage conditions, and therapeutic class when using this medication.

DosageInstructions

• For mild to moderate infections: 1-2 tablets twice daily
• For severe infections: 1.5-2 tablets twice daily
• Long term therapy (>14 days): 0.5-1 tablet twice daily

Indications

• Respiratory tract infections
• Genito-urinary tract infections
• Gastro-intestinal tract infections
• Osteomyelitis
• Skin infections
• Septicaemia
• Dysentery
• Cholera

ModeOfAction

Cotrimoxazole exerts its bactericidal action by the sequential blockade of two bacterial enzyme systems in the biosynthesis of folinic acid in microorganisms.

Contraindications

• Hypersensitivity to trimethoprim or sulphonamides
• Megaloblastic anemia due to folate deficiency
• Liver parenchymal damage
• Severe renal insufficiency
• Glucose 6-phosphate dehydrogenase deficiency

SideEffects

• Crystalluria
• Allergic reactions
• Haemolysis
• Thrombocytopenia
• Neutropenia
• Agranulocytosis
• Malaise
• Headache
• Nausea
• Vomiting

PregnancyAndLactation

Avoid during pregnancy and nursing period due to potential adverse effects on the baby.

PrecautionsAndWarnings

Prolonged full-dose treatment has the risk of macrocytic anemia. Caution with diabetic patients receiving sulphonylurea drug.

TherapeuticClass

Anti-diarrhoeal antimicrobial drugs, Sulphonamides & Trimethoprim

StorageConditions

Store below 30°C, away from light and moisture, out of reach of children