Gastab 150 mg (Tablet)
Unit Price: ৳ 2.01 (10 x 10: ৳ 201.00)
Strip Price: ৳ 20.10
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Nipro jmi pharma ltd |
| Also available as |
Title
- Gastab Ranitidine Tablets
Categories
- Medicine
- Gastrointestinal Health
- Acid Reducer
Dosage Forms
- Tablet
- Syrup
- Injection
- Infusion
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Postoperative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastrointestinal hemorrhage from stress ulcer in seriously ill patients
- Recurrent hemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patients at risk of acid aspiration, particularly obstetric patients
Pharmacology
- Competitively blocks histamine at H2-receptors of the gastric parietal cells
- Inhibits gastric acid secretion
- Does not affect pepsin secretion, pentagastrin-stimulated intrinsic factor secretion, or serum gastrin
Dosage And Administration
- 150 mg twice daily for active duodenal and benign gastric ulcers
- 300 mg as a single daily dose at night for 4 to 8 weeks for duodenal and gastric ulcers
- 150 mg twice daily for reflux esophagitis
- 300 mg at bedtime for up to 8 weeks for reflux esophagitis
- 150 mg 3 times daily for Zollinger-Ellison syndrome
- 150 mg twice daily for episodic dyspepsia
- 300 mg at bedtime for up to 6 weeks for episodic dyspepsia
- 150 mg at night for maintenance
- 2-4 mg/kg twice daily for children with peptic ulcer, maximum 300 mg daily in children
- Ranitidine injection may be given as a slow intravenous injection, intermittent intravenous infusion, or intramuscular injection
- Recommended oral dose for the treatment of peptic ulcer in children is 2 mg/kg to 4 mg/kg twice daily to a maximum of 300 mg ranitidine per day
- Dosage adjustment for reduced renal and hepatic function
Interaction
- Delayed absorption and increased peak serum concentration with propantheline bromide
- Minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam, and propranolol
- May alter absorption of pH-dependent drugs (e.g., ketoconazole, midazolam, glipizide)
- May reduce bioavailability with antacids
Contraindications
- Hypersensitivity to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy And Lactation
- Crosses the placenta
- No evidence of impaired fertility or harm to the fetus
- Excreted in human breast milk
- Caution in nursing mothers
Precautions And Warnings
- Use in reduced dosage for patients with impaired renal and hepatic function
Special Populations
- Use in elderly patients
- Similar ulcer healing rates in patients age 65 and over as in younger patients
- No difference in the incidence of adverse effects in elderly patients
Overdose Effects
- Specific in action with no particular problems expected following overdosage
- Symptomatic and supportive therapy as appropriate
- Possible removal from the plasma by hemodialysis if required
Therapeutic Class
- H2 receptor antagonist
Reconstitution
- Slow IV injection with NaCl 0.9% injection or dextrose 5% or 10%, lactated Ringer's, or Na bicarbonate 5% solution
- Intermittent slow IV infusion with dextrose 5% injection or NaCl 0.9%, lactated Ringer's, or Na bicarbonate 5% solution
- Continuous IV infusion with dextrose 5% injection or NaCl 0.9%, lactated Ringer's, or Na bicarbonate 5% solution
- Special dilution for patients with Zollinger-Ellison syndrome or other hypersecretory conditions
Storage Conditions
- Cool and dry place
- Protect from light