Hi Floxin 400 mg+80 mg (Tablet)

Medicine Details

Category Details
Generic Sulphamethoxazole trimethoprim
Company Hudson pharmaceuticals ltd
Also available as
Seftrim ds 800 mg tablet Seftrim 200 mg suspension Hi floxin 200 mg suspension

Title

  • Cotrimoxazole Tablet

Categories

  • Antibiotics
  • Antimicrobial Drugs
  • Sulphonamides
  • Trimethoprim

Description

  • A bactericidal tablet with broad spectrum activity against a wide range of gram-positive and gram-negative bacteria.

Packaging dimensions

5cm x 5cm x 10cm

Weight

100 grams

Color options

  • White

Active ingredients

  • Trimethoprim
  • Sulphamethoxazole

Strength

Double Strength

Dosage form

  • Tablet
  • Suspension

Age recommendation

Over 12 years for double strength tablet, under 12 years for suspension

Indications

  • Respiratory tract infections treatment and prophylaxis
  • Genito-urinary tract infections treatment
  • Gastro-intestinal tract infections caused by specific bacteria
  • Other infections confirmed to be susceptible to Cotrimoxazole

Pharmacology

Exerts its bactericidal action by sequential blockade of two bacterial enzyme systems

Dosage administration

  • Double strength tablet:
    • Mild to moderate infections: 1-1.5 tablets twice daily
    • Severe infections: 1.5 tablets twice daily
    • Long term therapy (>14 days): 0.5-1 tablet twice daily
    • Gonorrhoea: 2 tablets every 12 hours for two days or 2.5 tablets followed by a further dose of 2.5 tablets after 8 hours
  • Tablet:
    • Mild to moderate infections: 2 tablets twice daily
    • Severe infections: 2 tablets thrice daily
    • Long term therapy (>14 days): 1 tablet twice daily
  • Suspension:
    • 6-12 years: 2 teaspoonful twice daily
    • 6 month-5 years: 1 teaspoonful twice daily
    • 6 weeks-6 months: 0.5 teaspoonful twice daily

Contraindications

  • Hypersensitivity to trimethoprim or sulphonamides
  • Megaloblastic anaemia due to folate deficiency
  • Marked liver parenchymal damage, blood dyscrasia, severe renal insufficiency, glucose 6-phosphate dehydrogenase deficiency

Side effects

  • Crystalluria
  • Allergic reactions
  • Haemolysis
  • Thrombocytopenia
  • Neutropenia
  • Agranulocytosis
  • Malaise
  • Headache
  • Nausea
  • Vomiting

Pregnancy lactation

Avoid during pregnancy and nursing period

Precautions warnings

  • Prolonged full dose treatment associated with the risk of macrocytic anaemia
  • Care when giving to diabetic patients receiving sulphonylurea drug for possible potentiation of action

Therapeutic class

  • Antidiarrheal Antimicrobial drugs
  • Sulphonamides & Trimethoprim

Storage conditions

Keep below 30°C, away from light & moisture, out of the reach of children

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