Gepin 75 mg/5 ml (Syrup)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Post operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal haemorrhage from stress ulcer in seriously ill patient
- Recurrent haemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patient considered to be at risk of acid aspiration particularly obstetric patients
Pharmacology
Blocks histamine at H2-receptors of the gastric parietal cells, inhibiting gastric acid secretion, without affecting pepsin secretion, pentagastrin-stimulated intrinsic factor secretion, or serum gastrin.
Dosage & Administration
- Ranitidine Tablet & Syrup:
- 150 mg twice daily for 4 to 8 weeks in duodenal and gastric ulcer treatment
- 150 mg twice daily for up to 8 weeks in reflux oesophagitis
- 150 mg 3 times daily for Zollinger Ellison syndrome
- 150 mg twice daily for episodic dyspepsia
- 150 mg at night for maintenance
- 2-4 mg/kg twice daily for children (peptic ulcer)
- Ranitidine IV injection & IV Infusion: Various dosage forms and schedules for different conditions, including prophylaxis of haemorrhage from stress ulceration and upper gastrointestinal haemorrhage, with specific recommendations for children
Interaction
Delayed absorption and increased peak serum concentration with propantheline bromide. Gepin minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam and propanolol. May alter absorption of pH-dependent drugs and reduce bioavailability with antacids.
Contraindications
Hypersensitivity to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Pregnancy: Crosses the placenta, caution advised for use during pregnancy
- Lactation: Excreted in human breast milk, caution advised for use during lactation
Precautions & Warnings
Use in reduced dosage for patients with impaired renal and hepatic function
Use in Special Populations
No significant difference in ulcer healing rates or adverse effects in elderly patients as compared to younger patients
Overdose Effects
Specific in action, with no particular problems expected following overdosage. Symptomatic and supportive therapy recommended, with the option of haemodialysis if required
Therapeutic Class
H2 receptor antagonist
Reconstitution
- Slow IV inj: Specific dilution recommendations for different concentrations and infusion methods, with special instructions for patients with hypersecretory conditions
Storage Conditions
Store in a cool and dry place, protect from light