Gepin 50 mg/2 ml (IM/IV Injection)
2 ml ampoule: ৳ 10.03 (2 x 5: ৳ 100.30)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Post operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal haemorrhage from stress ulcer in seriously ill patient
- Recurrent haemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patient considered to be at risk of acid aspiration particulary obstetric patients
Pharmacology
- Competitively blocks histamine at H2-receptors
- Inhibits gastric acid secretion
- Does not affect pepsin secretion
- Does not affect pentagastrin-stimulated intrinsic factor secretion
- Does not affect serum gastrin
Dosage & Administration
- Usual dosage of 150 mg twice daily for 4 to 8 weeks
- Usual dosage of 300 mg as a single daily dose at night for 4 to 8 weeks
- Dosage of 150 mg twice daily for reflux oesophagitis
- Dosage of 300 mg at bedtime for reflux oesophagitis
- Dosage of 150 mg 3 times daily for Zollinger Ellison syndrome
- Dosage continued as long as clinically indicated for Zollinger Ellison syndrome
- Dosage of 150 mg twice daily for episodic dyspepsia
- Dosage of 300 mg at bedtime for episodic dyspepsia
- Maintenance dosage of 150 mg at night for preventing recurrences
- Children's dosage: 2-4 mg/kg twice daily, maximum 300 mg daily
- Different dosages for IV injection & IV infusion
Interaction
May interact with propantheline bromide, coumarin anticoagulants, theophylline, diazepam, propanolol, pH-dependent drugs, and antacids.
Contraindications
Patients hypersensitive to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Ranitidine crosses the placenta
- No evidence of impaired fertility or harm to the fetus
- Use during pregnancy only if considered essential
- Ranitidine excreted in human breast milk
- Caution when administered to a nursing mother
Precautions & Warnings
Given in reduced dosage to patients with impaired renal and hepatic function
Use in Special Populations
Ulcer healing rates similar in elderly patients as in younger patients
Overdose Effects
No particular problems expected following overdosage with the drug
Therapeutic Class
H2 receptor antagonist
Reconstitution
- Specific instructions for slow IV inj, intermittent slow IV infusion, continuous IV infusion of Gepin
Storage Conditions
Store in a cool and dry place, protect from light