Hi Tac 150 mg (Tablet)
Unit Price: ৳ 2.00 (100's pack: ৳ 200.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Hudson pharmaceuticals ltd |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Post operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal haemorrhage from stress ulcer in seriously ill patient
- Recurrent haemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patient considered to be at risk of acid aspiration particularly obstetric patients
Pharmacology
- Competitively blocks histamine at H2-receptors
- Inhibits gastric acid secretion
- Does not affect pepsin secretion
- Does not affect pentagastrin-stimulated intrinsic factor secretion
- Does not affect serum gastrin
Dosage & Administration
- Usual dosage of 150 mg twice daily for duodenal and gastric ulcer
- 300 mg as a single daily dose at night for 4 to 8 weeks for duodenal and gastric ulcer
- 150 mg twice daily for reflux oesophagitis
- 150 mg at bed time for up to 8 weeks for reflux oesophagitis
- 150 mg 3 times daily for Zollinger Ellison syndrome
- Episodic dyspepsia dosage of 150 mg twice daily
- 300 mg at bed time for up to 8 weeks for episodic dyspepsia
- Maintenance dosage of 150 mg at night for preventing recurrences
- 2-4 mg/kg twice daily for children with peptic ulcer
- Maximum 300 mg daily for children with peptic ulcer
- Slow (over a period of at least two minutes) intravenous injection of 50 mg
- Intermittent intravenous infusion at a rate of 25 mg per hour for two hours
- Intramuscular injection of 50 mg (2 ml) every six to eight hours
- Continuous intravenous infusion of 0.125-0.250 mg/kg/hour for prophylaxis of upper gastrointestinal haemorrhage from stress ulceration
- Intramuscular or slow intravenous injection of 50 mg 45 to 60 minutes before induction of general anaesthesia for patients at risk of developing aspiration syndrome
- Oral dose for the treatment of peptic ulcer in children is 2 mg/kg to 4 mg/kg twice daily to a maximum of 300 mg ranitidine per day
Interaction
- Delayed absorption and increased peak serum concentration with propantheline bromide
- Minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam, and propanolol
- May alter absorption of pH-dependent drugs (e.g. ketoconazole, midazolam, glipizide)
- May reduce bioavailability with antacids
Contraindications
- Hypersensitivity to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Ranitidine crosses the placenta
- No evidence of impaired fertility or harm to the foetus due to Ranitidine
- Caution should be exercised when administered to a nursing mother
Precautions & Warnings
- Given in reduced dosage to patients with impaired renal and hepatic function
Use in Special Populations
- Similar ulcer healing rates in patients age 65 and over as in younger patients
- No difference in the incidence of adverse effects between elderly and younger patients
Overdose Effects
- No particular problems expected following overdosage
- Symptomatic and supportive therapy should be given as appropriate
- Drug may be removed from the plasma by haemodiaiysis if required
Therapeutic Class
- H2 receptor antagonist
Reconstitution
- Slow IV inj of Hi Tac 50 mg diluted to a concentration ≤2.5 mg/mL with appropriate solution
- Intermittent slow IV infusion of Hi Tac 50 mg diluted to a concentration ≤0.5 mg/mL with appropriate solution
- Continuous IV infusion of Hi Tac 150 mg diluted in 250 mL of appropriate solution
- Dilution to a concentration ≤2.5 mg/mL with appropriate solution for Zollinger-Ellison syndrome or other hypersecretory conditions
Storage Conditions
- Store in a cool and dry place
- Protect from light