NovoSeven 1 mg/vial (IV Injection)
1 mg vial: ৳ 81,200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Coagulation factor viia eptacog alfa |
| Company | Novo nordisk pharma pvt ltd |
Indications
- Bleeding episodes in patients with haemophilia
- Bleeding episodes due to surgery or invasive procedures in patients with factor VII deficiency
- Bleeding episodes due to surgery or invasive procedures in Glanzmann's thrombasthenia
Pharmacology
- Recombinant factor VIIa is a biosynthetic preparation of activated factor VII produced by recombinant DNA technology
- It is a vitamin K-dependent glycoprotein
- It promotes haemostasis by activating the extrinsic pathway of the coagulation cascade
- It replaces deficient activated coagulation factor VII, which complexes with tissue factor and may activate coagulation factor X and factor IX
- Factor VIIa is given as the recombinant form, eptacog alfa (activated)
Dosage & Administration
- Initial dose of 90 mcg/kg given via IV bolus over 2-5 min for bleeding episodes in patients with haemophilia
- Additional dose may be given as needed to achieve or maintain haemostasis
- 15-30 mcg/kg 4-6 hrly via IV bolus over 2-5 min for bleeding episodes due to surgery or invasive procedures in patients with factor VII deficiency
- 90 mcg/kg 2 hrly via IV bolus over 2-5 min, give at least 3 doses for bleeding episodes due to surgery or invasive procedures in Glanzmann's thrombasthenia
Interaction
Increased risk of thromboembolism with activated or non-activated prothrombin complex concentrate
Contraindications
- Hypersensitivity to recombinant coagulation factor VIIa or to mouse, hamster or bovine protein
- Rare hereditary problems of fructose intolerance, glucose malabsorption or sucrose-isomaltase insufficiency
Side Effects
- Nausea
- Vomiting
- Skin reactions
- Fever
- Headache
- Changes in blood pressure
- Rarely, anaphylaxis
Pregnancy & Lactation
- It is preferable to avoid use during pregnancy
- Potential risk to the fetus
- Unknown excretion of eptacog alfa in human breast milk
Precautions & Warnings
- Advanced atherosclerotic disease
- Crush injury
- Septicemia or disseminated intravascular coagulation
- Patients with history of CHD
- Liver disease
- Undergoing major surgery
- At risk of thromboembolic phenomena or disseminated intravascular coagulation
- Remote possibility of hypersensitivity to mouse IgG, bovine IgG & other residual culture proteins
- Monitor prothrombin time & factor VII coagulant activity in factor VII deficient patients
- Pregnancy & lactation
- Neonates
Therapeutic Class
Anti-fibrinolytic drugs
Reconstitution
Add the recommended diluent (histidine), swirl gently until dissolved
Storage Conditions
Store between 2-25° C prior to reconstitution, do not freeze, protect from light