Empa 10 mg (Tablet)

Indications

• Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus
• Reduce the risk of cardiovascular death in adult patients with type 2 diabetes mellitus and established cardiovascular disease

Pharmacology

• Sodium glucose co-transporter-2 (SGLT-2) inhibitor
• Reduces renal absorption of glucose
• Assists in weight loss
• Lowers blood pressure

Dosage & Administration

• Recommended dose: 10 mg once daily
• May be increased to 25 mg once daily in patients tolerating
• Recommended to be taken in the morning, with or without food
• Correction of volume depletion prior to initiation is recommended

Interaction

• Co-administration with diuretics increases urine volume
• Co-administration with insulin or insulin secretagogues increases the risk for hypoglycemia
• Monitoring glycemic control with urine glucose tests is not recommended
• Monitoring glycemic control with 1,5-AG assay is not recommended

Contraindications

• History of serious hypersensitivity reaction to Empagliflozin or its ingredients
• Severe renal impairment
• End-stage renal disease
• Dialysis

Side Effects

• Urinary tract infections
• Female genital mycotic infections
• Dehydration
• Hypotension
• Weakness
• Dizziness
• Increased thirstiness

Pregnancy & Lactation

• No adequate and well-controlled studies in pregnant women
• Use during pregnancy only if potential benefit justifies potential risk to the fetus
• Not recommended when breastfeeding

Precautions & Warnings

• Assessment of renal function recommended prior to initiation
• Not initiated in patients with eGFR less than 45 ml/min/1.73 m^2
• No dose adjustment needed in patients with eGFR greater than or equal to 45 ml/min/1.73 m^2

Overdose Effects

• Supportive measures such as removal of unabsorbed material and clinical monitoring should be employed
• Removal by hemodialysis has not been studied

Therapeutic Class

• Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors

Storage Conditions

• Keep in a cool & dry place (below 30° C)
• Protected from light & moisture
• Keep out of the reach of children

Chemical Structure

• Molecular Formula: C23H27ClO7

Common Questions about Empa 10 mg Tablet

• Used to improve glycemic control in adults
• May be unsafe to use during pregnancy
• Probably unsafe to use during breastfeeding
• Should be used cautiously in patients with underlying kidney disease
• No dose adjustment needed for patients with mild to moderate liver disease

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