Neoceptin R 150 mg (Tablet)
Unit Price: ৳ 3.00 (15 x 10: ৳ 450.00)
Strip Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Title
- Neoceptin R
Categories
- Medicine
- Pharmaceutical
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Post operative stress ulcer
- Zollinger-Ellison Syndrome.
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal haemorrhage from stress ulcer in seriously ill patient
- Recurrent haemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patient considered to be at risk of acid aspiration particularly obstetric patients
Mode of Action
- Blocks histamine at H2-receptors of the gastric parietal cells
- Inhibits gastric acid secretion
- Does not affect pepsin secretion
- Does not affect pentagastrin-stimulated intrinsic factor secretion
- Does not affect serum gastrin
Dosage & Administration
- Usual dosage of 150 mg twice daily for 4 to 8 weeks for duodenal and gastric ulcer
- Usual dosage of 150 mg twice daily for up to 8 weeks for reflux oesophagitis
- Usual dosage of 150 mg 3 times daily for Zollinger Ellison syndrome
- Dosage of 150 mg twice daily for up to 6 weeks for episodic dyspepsia
- Maintenance dosage of 150 mg at night for preventing recurrences
- Recommended oral dose for the treatment of peptic ulcer in children is 2 mg/kg to 4 mg/kg twice daily to a maximum of 300 mg ranitidine per day
- Ranitidine IV injection may be given slowly intravenous or as an intermittent intravenous infusion
- In the prophylaxis of upper gastrointestinal haemorrhage from stress ulceration in seriously ill patient sapriming dose of 50 mg as low as intravenous injection followed by a continuous intravenous infusion of 0.125-0.250 mg/kg/hour may be preferred
Interaction
- Delayed absorption and increased peak serum concentration with propantheline bromide
- Minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam and propanolol
- May alter absorption of pH-dependent drugs (e.g. ketoconazole, midazolam, glipizide)
- May reduce bioavailability with antacids
Contraindications
- Patients hypersensitive to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Ranitidine crosses the placenta
- No evidence of impaired fertility or harm to the fetus due to Ranitidine
- Ranitidine should only be used during pregnancy if considered essential
- Ranitidine is excreted in human breast milk
- Caution should be exercised when the drug is administered to a nursing mother
Precautions & Warnings
- Should be given in reduced dosage to patients with impaired renal and hepatic function
Use in Special Populations
- Ulcer healing rates have been found similar in elderly patients with those in younger patients
- No difference in the incidence of adverse effects in elderly patients
Overdose Effects
- No particular problems are expected following overdosage with the drug
- Symptomatic and supportive therapy should be given as appropriate
- The drug may be removed from the plasma by hemodialysis if required
Therapeutic Class
- H2 receptor antagonist
Reconstitution
- Slow IV injection
- Intermittent slow IV infusion
- Continuous IV infusion
- Patients with Zollinger-Ellison syndrome or other hypersecretory conditions should be diluted to a concentration ≤2.5 mg/mL with dextrose 5% or NaCl 0.9%, lactated Ringer's, Na bicarbonate 5% soln.
Storage Conditions
- Store in a cool and dry place
- Protect from light