Esotor 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 10.00 (4 x 10: ৳ 400.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Esomeprazole
Company Nipro jmi pharma ltd
Also available as
Esotor 20 mg capsule Esotor 20 mg tablet Esotor 40 mg tablet

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Zollinger-Ellison Syndrome
  • Acid-related Dyspepsia
  • Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppression of gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase
  • Peak plasma levels occur at approximately 1.5 hours after oral administration
  • Extensively metabolized in the liver
  • Plasma protein binding is constant over the concentration range
  • The plasma elimination half-life is approximately 1–1.5 hours

Dosage

  • 20 mg or 40 mg Once Daily for 4-8 Weeks for Healing of Erosive Esophagitis
  • 20 mg Once Daily for Maintenance of Healing of Erosive Esophagitis
  • 20 mg Once Daily for Symptomatic GERD
  • Triple Therapy for Helicobacter pylori eradication
  • 20-80 mg Once Daily for Zollinger-Ellison Syndrome
  • 20-40 mg Once Daily for Acid-related Dyspepsia
  • 20 mg Once Daily for 2-4 weeks for Duodenal ulcer

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension should be taken after mixing with water
  • IV Injection: 20 mg or 40 mg for adult patients, dosages for pediatric patients
  • IV Infusion for risk reduction of rebleeding of Gastric or Duodenal Ulcers following therapeutic endoscopy in adults

Interaction

  • Extensively metabolized by CYP2C19 and CYP3A4
  • No clinically significant interactions with certain drugs
  • Potential interference with CYP2C19 and gastric pH-dependent drugs
  • Increased plasma levels when co-administered with clarithromycin and amoxicillin

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects in animal studies
  • Excretion in milk not studied, breastfeeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Instructions for patients on capsule administration
  • Use of antacids while taking Esotor

Use in Special Populations

  • No established safety and effectiveness in pediatric patients
  • No overall differences in safety and efficacy observed in the elderly
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in renal impairment

Overdose Effects

  • Acute toxicity signs in animal studies
  • No specific antidote known
  • Treatment should be symptomatic and supportive

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Common Questions about Esotor 40 mg Capsule

  • Purpose of Esotor 40 mg Capsule
  • Uses of Esotor 40 mg Capsule
  • Common side effects of Esotor 40 mg Capsule
  • Pregnancy and breastfeeding precautions
  • Onset of action of Esotor 40 mg Capsule
  • Quick tips for using Esotor 40 mg Capsule

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