Nixon 250 mg/vial (IM Injection)

250 mg vial: ৳ 110.33

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Nipro jmi pharma ltd
Also available as
Nixon 250 mg injection Nixon 500 mg injection Nixon 500 mg injection Nixon 1 gm injection Nixon 1 gm injection Nixon 2 gm injection

Category

  • Medicine
  • Pharmaceutical

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Broad-spectrum parenteral cephalosporin antibiotic
  • Potent bactericidal activity
  • Interferes with bacterial cell wall synthesis
  • Long plasma elimination half-life (6 to 9 hours)
  • High stability in the presence of beta lactamases
  • Highly protein bound (95%)
  • Not metabolized in the body
  • Excreted unchanged in urine and bile

Dosage

  • Adult dose: 1 to 2 gm by intravenous or intramuscular administration once a day
  • Infants and Children dose: 50 to 75 mg/kg intravenous or intramuscular administration once a day
  • Maximum adult dose: 4 gm/day
  • Maximum pediatric dose: 2 gm/day
  • Dosage duration: 4 to 14 days (usual)

Administration

  • Intravenous and Intramuscular injection
  • Preparation of solutions for injections
  • Administered over 2-4 minutes
  • Freshly reconstituted solution recommended
  • Patient tolerance test recommended

Interaction

  • No reported drug interactions

Contraindications

  • Hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects (diarrhea, nausea, vomiting)
  • Cutaneous reactions (rash, pruritus, urticaria)
  • Hematologic reactions (eosinophilia, thrombocytopenia)
  • Hepatic reactions (elevations of SGOT, SGPT, bilirubin)
  • CNS reactions (nervousness, confusion, headache)
  • Local phlebitis following intravenous administration

Pregnancy & Lactation

  • Safety not established in human pregnancy
  • Caution during lactation

Precautions & Warnings

  • Risk of anaphylactic shock
  • Possible gallbladder sludge
  • Regular blood picture checks during prolonged treatment

Use in Special Populations

  • Avoid use in premature and newborn neonates (up to 28 days of age)

Overdose Effects

  • No specific antidote
  • Symptomatic treatment recommended

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Store in a cool, dry place (below 30°C)
  • Keep away from light & moisture
  • Keep out of the reach of children

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