Nixon 500 mg/vial (IM Injection)

500 mg vial: ৳ 150.45

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Nipro jmi pharma ltd
Also available as
Nixon 250 mg injection Nixon 250 mg injection Nixon 500 mg injection Nixon 1 gm injection Nixon 1 gm injection Nixon 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Broad-spectrum parenteral cephalosporin antibiotic
  • Bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Interferes with the synthesis of bacterial cell wall
  • High stability in the presence of beta lactamases
  • Relatively long plasma elimination half-life of about 6 to 9 hours
  • Not metabolized in the body
  • Highly protein bound (95%)

Dosage

  • Usual dose of 1 to 2 gm by intravenous or intramuscular administration once a day
  • Maximum dose of 4 gm/day for adults
  • Usual dose of 50 to 75 mg/kg intravenous or intramuscular administration once a day for infants and children
  • Maximum dose of 2 gm/day for infants and children
  • Continue therapy for more than 2 days after signs and symptoms of infection have disappeared

Administration

  • Preparation of Solutions for Intramuscular / Intravenous Injections
  • Injection should be administered over 2-4 minutes
  • Patient tolerance test should be checked before starting treatment through Ceftriaxone injection

Interaction

  • No drug interactions reported

Contraindications

  • Should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastrointestinal effects including diarrhea, nausea, vomiting, stomatitis, and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema, and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia, and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia, and dizziness
  • Local phlebitis occurs rarely following intravenous administration

Pregnancy & Lactation

  • Safety in human pregnancy not established
  • Caution when administered to a lactating mother

Precautions & Warnings

  • Anaphylactic shock cannot be ruled out
  • Shadows suggesting sludge have been detected by sonograms of the gallbladder in rare cases
  • Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

  • Must not be given to neonates if premature and newborn (up to 28 days of age)

Overdose Effects

  • No specific antidote
  • Treatment of overdosage should be symptomatic

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Vial should be stored in a cool, dry place (below 30° C), away from light and moisture
  • Keep out of the reach of children

Related Brands