Nixon 500 mg/vial (IV Injection)

500 mg vial: ৳ 150.45

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Nipro jmi pharma ltd
Also available as
Nixon 250 mg injection Nixon 250 mg injection Nixon 500 mg injection Nixon 1 gm injection Nixon 1 gm injection Nixon 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms.

Dosage

  • Adult:
    • 1 to 2 gm by intravenous or intramuscular administration once a day
    • In equally divided doses twice a day
  • Infants and Children (01 month or older):
    • 50 to 75 mg/kg intravenous or intramuscular administration once a day
    • In equally divided doses twice a day

Administration

  • Preparation of Solutions for Intramuscular / Intravenous Injections:
    • For Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in 2 ml Lidocaine HCI 1% injection or 1 g Ceftriaxone in 3.5 ml of Lidocaine HCI 1% injection
    • For Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in 5 ml of Water for injection or 1 g Ceftriaxone in 10 ml of Water for injection USP or 2 g Ceftriaxone in 20 ml of Water for injection.

Interaction

No drug interactions have been reported.

Contraindications

Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics.

Side Effects

  • Gastro-intestinal effects:
    • Diarrhea
    • Nausea
    • Vomiting
    • Stomatitis
    • Glossitis
  • Cutaneous reactions:
    • Rash
    • Pruritus
    • Urticaria
    • Edema
    • Erythema multiforme
  • Hematologic reactions:
    • Eosinophilia
    • Thrombocytopenia
    • Leucopenia
    • Anemia
    • Neutropenia
  • Hepatic reactions:
    • Elevations of SGOT or SGPT
    • Bilirubinemia
  • CNS reactions:
    • Nervousness
    • Confusion
    • Sleep disturbances
    • Headache
    • Hyperactivity
  • Local phlebitis: Rarely occurs following intravenous administration and can be minimized by slow injections over 2-4 minutes.

Pregnancy & Lactation

Its safety in human pregnancy has not been established. Therefore, it should not be used in pregnancy unless absolutely indicated. Caution should be exercised when Ceftriaxone is administered to a lactating mother.

Precautions & Warnings

  • Anaphylactic shock: Cannot be ruled out even if a thorough patient history is taken. Requires immediate countermeasures such as intravenous epinephrine followed by a glucocorticoid.
  • Gallbladder condition: May be detected by sonograms, and if associated with pain, conservative, nonsurgical management is recommended.
  • Blood picture: Should be checked at regular intervals during prolonged treatment.

Use in Special Populations

Nixon must not be given to neonates if the neonates is premature and newborn (up to 28 days of age).

Overdose Effects

There is no specific antidote. Treatment of overdosage should be symptomatic.

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial should be stored in a cool, dry place (below 30°C), away from light and moisture. Keep out of the reach of children.

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