Nixon 1 gm/vial (IV Injection)

1 gm vial: ৳ 220.66

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Nipro jmi pharma ltd
Also available as
Nixon 250 mg injection Nixon 250 mg injection Nixon 500 mg injection Nixon 500 mg injection Nixon 1 gm injection Nixon 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Broad-spectrum parenteral cephalosporin antibiotic
  • Bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Interferes with the synthesis of the bacterial cell wall
  • Long plasma elimination half-life of about 6 to 9 hours
  • Not metabolized in the body
  • Highly protein bound (95%)

Dosage

  • Usual dose is 1 to 2 gm by intravenous or intramuscular administration once a day
  • Maximum dose: 4 gm/day for adults
  • Usual dose is 50 to 75 mg/kg intravenous or intramuscular administration once a day for infants and children (01 month or older)
  • Maximum dose: 2 gm/day for infants and children
  • Duration of therapy: 4 to 14 days; in complicated infections, longer therapy may be required

Administration

  • Intramuscular or intravenous administration
  • Preparation of Solutions for Intramuscular / Intravenous Injections using Lidocaine HCI 1% injection or Water for injection USP
  • Injection should be administered over 2-4 minutes, by Intramuscular or Intravenous injection or by tubing infusion over a period of 30 minutes
  • Use of freshly reconstituted solution is recommended

Interaction

No drug interactions have been reported

Contraindications

Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
  • Local phlebitis occurs rarely following intravenous administration but can be minimized by slow injections over 2-4 minutes

Pregnancy & Lactation

Safety in human pregnancy has not been established; caution should be exercised when Ceftriaxone is administered to a lactating mother

Precautions & Warnings

  • Anaphylactic shock cannot be ruled out
  • Shadows suggesting sludge have been detected by sonograms of the gallbladder
  • Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

Must not be given to neonates if the neonate is premature and newborn (up to 28 days of age)

Overdose Effects

No specific antidote; treatment of overdosage should be symptomatic

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial store in a cool, dry place (below 30° C), away from light & moisture; Keep out of the reach of children

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