Linatab M 2.5 mg+850 mg (Tablet)
Unit Price: ৳ 14.00 (3 x 10: ৳ 420.00)
Strip Price: ৳ 140.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Linagliptin metformin hydrochloride |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Therapeutic Class
- Combination Oral hypoglycemic preparations
Indications
- Adjunct to diet and exercise
- Improve glycemic control in adults with type 2 diabetes mellitus
Pharmacology
- Linagliptin inhibits DPP-4 enzyme
- Increases concentrations of active incretin hormones
- Stimulates insulin release from beta cells
- Decreases glucagon secretion from alpha cells
- Metformin lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Individualized based on effectiveness and tolerability
- Maximum recommended dose of 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride twice daily with meals
- Gradual dose escalation to reduce gastrointestinal side effects
Interaction
- Cationic drugs may interact with Metformin
- Carbonic Anhydrase Inhibitors may induce metabolic acidosis
- Inducers of P-glycoprotein and CYP3A4 Enzymes may reduce Linagliptin efficacy
- Drugs affecting glycemic control may lead to loss of control
Contraindications
- Renal impairment
- Metabolic acidosis (diabetic ketoacidosis)
- Hypersensitivity to Linagliptin or Metformin Hydrochloride
Side Effects
- Nasopharyngitis
- Diarrhea
- Hypoglycemia
Pregnancy & Lactation
- Use during pregnancy only if clearly needed
- Exercise caution during lactation
Precautions & Warnings
- Discontinue in case of lactic acidosis or pancreatitis
- Temporarily discontinue before radiologic studies or surgical procedures
- Monitor Vitamin B12 levels
- Be cautious with alcohol and other medicines
- Be prepared for diabetes-related emergencies
- Instructions about travel and emergency situations
Overdose Effects
- Supportive measures
- Dialyzable Metformin Hydrochloride
- No dose-related clinical adverse drug reactions for Linagliptin
- Hypoglycemia and lactic acidosis reported for Metformin Hydrochloride overdose
Storage Conditions
- Keep in a cool and dry place (below 30°C)
- Protected from light and moisture
- Keep out of the reach of children