Linaglip-M 2.5 mg+850 mg (Tablet)

Unit Price: ৳ 16.00 (3 x 10: ৳ 480.00)
Strip Price: ৳ 160.00

Medicine Details

Category Details
Generic Linagliptin metformin hydrochloride
Company Aristopharma ltd
Also available as
Linaglip m 25 mg tablet Linaglip m er 5 mg tablet

Indications

  • Adjunct to diet and exercise
  • Improves glycemic control in adults with type 2 diabetes mellitus
  • Appropriate when treatment with Linagliptin and Metformin Hydrochloride is necessary

Pharmacology

  • Linagliptin is a DPP-4 inhibitor
  • Increases active incretin hormones
  • Stimulates insulin release and decreases glucagon secretion
  • Metformin is a biguanide antihyperglycemic drug
  • Lowers plasma glucose levels
  • Improves insulin sensitivity and utilization

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerability
  • Maximum recommended dose of 2.5mg Linagliptin and 1000mg Metformin twice daily with meals
  • Gradual dose escalation recommended to reduce GI side effects

Interactions

  • Potential interactions with cationic drugs
  • Interaction with carbonic anhydrase inhibitors may induce metabolic acidosis
  • Inducers of P-glycoprotein and CYP3A4 enzymes may reduce Linagliptin efficacy
  • Certain drugs affect glycemic control and may lead to hyperglycemia

Contraindications

  • Contraindicated in patients with renal impairment
  • Contraindicated in acute or chronic metabolic acidosis
  • Contraindicated in hypersensitivity to Linagliptin or Metformin Hydrochloride

Side Effects

  • Most common side effects are nasopharyngitis and diarrhea
  • Hypoglycemia more common with Linaglip-M and sulfonylureas

Pregnancy & Lactation

  • No adequate studies in pregnant women
  • Use during pregnancy only if clearly needed
  • Caution in lactating mothers

Precautions & Warnings

  • Discontinue in case of lactic acidosis
  • Monitor vitamin B12 levels annually
  • Alcohol consumption may cause low blood sugar
  • Family members should be aware of side effects

Overdose Effects

  • Supportive measures in case of overdose
  • Removal of unabsorbed material
  • Hemodialysis or peritoneal dialysis unlikely for Linagliptin
  • Metformin dialyzable
  • No dose-related adverse reactions for Linagliptin up to 600mg
  • Metformin overdose may lead to hypoglycemia and lactic acidosis

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Storage Conditions

  • Store below 30°C
  • Keep in a cool and dry place
  • Protect from light and moisture
  • Keep out of reach of children

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