SB-Metlina 2.5 mg+500 mg (Tablet)
Unit Price: ৳ 12.00 (30's pack: ৳ 360.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Linagliptin metformin hydrochloride |
| Company | Sunman birdem pharma ltd |
| Also available as |
Title and Categories
- Linagliptin & Metformin tablet
- Oral hypoglycemic drug
- Medicine for type 2 diabetes mellitus
Function
- Improves glycemic control in type 2 diabetes mellitus
- Increases concentrations of active incretin hormones
- Stimulates the release of insulin from pancreatic beta cells
- Decreases secretion of glucagon from pancreatic alpha cells
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
- Reduces gastrointestinal side effects
Dosage and Administration
- Maximum recommended dose of 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride twice daily
- Recommended starting dose: 2.5 mg Linagliptin and 500 mg Metformin Hydrochloride twice daily for patients not previously treated with Metformin
- Dose escalation should be gradual
- Dosage should be individualized based on effectiveness and tolerability
- Extended-release tablet should not exceed total daily dose of Linagliptin 5 mg and Metformin Hydrochloride 2000 mg
- Different starting doses for patients already treated with Metformin and/or Linagliptin
Interaction
- Potential interaction with cationic drugs eliminated by renal tubular secretion
- Concomitant use with carbonic anhydrase inhibitors may induce metabolic acidosis
- Rifampin decreased Linagliptin exposure
- Certain drugs may affect glycemic control
Contraindications
- Contraindicated in renal impairment
- Contraindicated in acute or chronic metabolic acidosis
- Contraindicated in hypersensitivity to Linagliptin or Metformin Hydrochloride
Side Effects
- Most common side effects: nasopharyngitis and diarrhea
- Hypoglycemia more common in patients treated with sulfonylureas
Pregnancy and Lactation
- Should be used during pregnancy only if clearly needed
- Caution should be exercised when administered to a lactating mother
Precautions and Warnings
- Discontinue in case of lactic acidosis or suspected pancreatitis
- Temporarily discontinue in certain medical procedures
- Metformin may lower Vitamin B12 levels
- Symptoms and precautions for lactic acidosis
- Precautions for alcohol, other medicines, counseling, travel, and emergencies
- May cause hypoglycemia
Overdose Effects
- Usual supportive measures should be employed
- Linagliptin is unlikely to be removed by dialysis
- Metformin Hydrochloride is dialyzable
- No dose-related clinical adverse drug reactions up to 600 mg of Linagliptin
- Reported hypoglycemia and lactic acidosis in Metformin Hydrochloride overdose cases
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Keep in a cool & dry place (below 30°C)
- Protected from light & moisture
- Keep out of the reach of children
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