SB-Metlina 2.5 mg+850 mg (Tablet)

Unit Price: ৳ 14.00 (30's pack: ৳ 420.00)

Medicine Details

Category Details
Generic Linagliptin metformin hydrochloride
Company Sunman birdem pharma ltd
Also available as
Sb metlina 25 mg tablet

Title and Categories

  • SB-Metlina Combination Oral hypoglycemic preparations

Dimensions

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      Functions

      • Improves glycemic control in adults with type 2 diabetes mellitus
      • Inhibits DPP-4 enzyme
      • Stimulates insulin release in a glucose-dependent manner
      • Decreases glucagon secretion
      • Lowers both basal and postprandial plasma glucose
      • Improves insulin sensitivity
      • Decreases hepatic glucose production
      • Decreases intestinal absorption of glucose
      • Increases peripheral glucose uptake and utilization

      Materials

        Technical Specifications

        • Dosage of 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride twice daily
        • Maximum recommended dose of 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride
        • Dosage individualized based on effectiveness and tolerability
        • Maximum recommended total daily dose of Linagliptin 5 mg and Metformin Hydrochloride 2000 mg
        • Dosage escalation should be gradual to reduce gastrointestinal side effects
        • Dosage individualized based on effectiveness and tolerability for extended-release tablet

        Design Elements

          Usability Features

          • Indicated as an adjunct to diet and exercise

          Indications

          • Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus

          Pharmacology

          • Linagliptin is an inhibitor of DPP-4 (dipeptidyl peptidase-4)
          • Linagliptin increases the concentrations of active incretin hormones
          • Linagliptin stimulates the release of insulin from pancreatic beta cells in a glucose-dependent manner
          • Linagliptin decreases the secretion of glucagon from pancreatic alpha cells
          • Metformin Hydrochloride is a biguanide type oral antihyperglycemic drug
          • Metformin Hydrochloride mechanism of action is different from sulfonylureas

          Dosage & Administration

          • Dosage should be individualized based on effectiveness and tolerability
          • Recommended starting dose based on previous treatment with Metformin Hydrochloride or Linagliptin

          Interaction

          • Potential interaction with cationic drugs eliminated by renal tubular secretion
          • Potential interaction with carbonic anhydrase inhibitors
          • Potentially reduced efficacy when administered with a strong P-gp or CYP 3A4 inducer
          • Certain drugs may affect glycemic control and lead to loss of control

          Contraindications

          • Contraindicated in patients with renal impairment
          • Contraindicated in acute or chronic metabolic acidosis (diabetic ketoacidosis)
          • Contraindicated in hypersensitivity to Linagliptin or Metformin Hydrochloride

          Side Effects

          • Common side effects include nasopharyngitis and diarrhea
          • Hypoglycemia is more common when combined with sulfonylureas

          Pregnancy & Lactation

          • Use during pregnancy only if clearly needed
          • Caution should be exercised when administered to a lactating mother

          Precautions & Warnings

          • Discontinue immediately and institute supportive therapy in case of lactic acidosis
          • Promptly discontinue in case of suspected pancreatitis
          • Temporarily discontinue during radiologic studies with contrast materials or surgical procedures
          • Hematologic parameters should be monitored annually for Vitamin B12 levels
          • Careful instructions on alcohol consumption, other medicines, counseling, travel, and emergencies
          • May cause hypoglycemia and should be treated promptly

          Overdose Effects

          • Usual supportive measures for overdose
          • Linagliptin is unlikely to be removed by dialysis
          • Metformin Hydrochloride is dialyzable
          • No dose-related clinical adverse drug reactions reported with Linagliptin overdose
          • Hypoglycemia and lactic acidosis reported with Metformin Hydrochloride overdose

          Therapeutic Class

          • Combination Oral hypoglycemic preparations

          Storage Conditions

          • Keep in a cool & dry place (below 30°C)
          • Protected from light & moisture
          • Keep out of the reach of children

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