Losarva Plus 50 mg+12.5 mg (Tablet)

Unit Price: ৳ 10.00 (5 x 10: ৳ 500.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Losartan potassium hydrochlorothiazide
Company Nipro jmi pharma ltd

Indications

  • Treatment of hypertension
  • Reduction of stroke risk in patients with hypertension and left ventricular hypertrophy

Pharmacology

  • Vasoconstrictor
  • Hypertension pathophysiology
  • Aldosterone secretion
  • Reversible competitive inhibitor
  • Diuretic effect
  • Renal tubular mechanisms of electrolyte reabsorption
  • Plasma volume reduction
  • Plasma renin activity
  • Potassium loss
  • ACE inhibition
  • Cardiovascular regulation

Dosage

  • Usual starting dose
  • Initial dose for left ventricular hypertrophy
  • Antihypertensive effect timeline
  • Elderly patient dosage
  • Severe hypertension treatment

Administration

  • May be administered with other antihypertensive agents
  • May be administered with or without food

Interaction

  • Drug-drug interactions
  • Potassium-sparing diuretics effect
  • NSAID interaction
  • Thiazide diuretics interactions
  • Antidiabetic drugs dosage adjustment
  • Cholestyramine and colestipol resins effect

Contraindications

  • Hypersensitivity to any component
  • Anuria
  • Hypersensitivity to sulfonamide-derived drugs

Side Effects

  • Symptomatic hypotension
  • Dizziness
  • Hyperkalaemia
  • Angioedema
  • Vertigo
  • Gastro-intestinal disturbances
  • Angina
  • Palpitation
  • Oedema
  • Dyspnoea
  • Headache
  • Sleep disorders
  • Malaise
  • Urticaria
  • Pruritus
  • Rash
  • Hepatitis
  • Atrial fibrillation
  • Cerebrovascular accident
  • Syncope
  • Pancreatitis
  • Anaphylaxis
  • Cough
  • Depression
  • Erectile dysfunction
  • Anaemia
  • Thrombocytopenia
  • Hyponatraemia
  • Arthralgia
  • Myalgia
  • Renal impairment
  • Rhabdomyolysis
  • Tinnitus
  • Photosensitivity
  • Vasculitis

Pregnancy & Lactation

  • Avoidance in pregnancy
  • Adverse effects on fetal and neonatal blood pressure control and renal function
  • Skull defects
  • Oligohydramnios
  • Limited information on breastfeeding use
  • Not recommended in breastfeeding
  • Alternative treatment options for breastfeeding

Precautions & Warnings

  • Angiooedema hypersensitivity
  • Periodic determination of serum electrolytes
  • Hypokalemia
  • Impaired renal function
  • Use in Patients with Renal Impairment
  • Use in Patients with Hepatic Impairment
  • Use in Pediatric Patients

Use in Special Populations

  • Renal impairment regimens
  • Severe renal impairment preference for loop diuretics
  • Use in patients with hepatic impairment not recommended
  • Safety and effectiveness in pediatric patients not established

Overdose Effects

  • Manifestations of overdosage
  • Hypotension
  • Tachycardia
  • Bradycardia
  • Supportive treatment
  • Hemodialysis removal

Therapeutic Class

  • Combined antihypertensive preparations

Storage Conditions

  • Temperature limitation
  • Child safety measure

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