Lyrinex 50 mg (Capsule)
Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Pregabalin |
| Company | Nipro jmi pharma ltd |
| Also available as |
Indications
- Neuropathic pain associated with diabetic peripheral neuropathy (DPN)
- Postherpetic neuralgia (PHN)
- Adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older
- Fibromyalgia
- Neuropathic pain associated with spinal cord injury
Pharmacology
Structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)
Dosage
- DPN in adults: Dosing range of 150-300 mg/day
- PHN in adults: Dosing range of 150-600 mg/day
- Fibromyalgia: Dosing range of 300-450 mg/day
- Spinal cord injury: Recommended dose range of 150-600 mg/day
- Conversion from Pregabalin capsules to Pregabalin CR capsule tablet: Guidelines provided
- Pregabalin tablet total daily dose:
- 75 mg/daily: 82.5 mg/day
- 150 mg/daily: 165 mg/day
- 225 mg/daily: 247.5 mg/day
- 300 mg/daily: 330 mg/day
- 450 mg/daily: 495 mg/day
- 600 mg/daily: 660 mg/day
Administration
- Route of administration: Oral
- Pregabalin CR tablet administration: After an evening meal, swallowed whole, not split, crushed, or chewed
- Discontinuation: Gradually tapered over a minimum of 1 week
Interaction
- Drug interaction with medication: Unlikely to be involved in significant pharmacokinetic drug interactions
- Drug interaction with food and others: Not applicable
Contraindications
Hypersensitivity to Pregabalin or any of its components
Side Effects
- Dizziness
- Somnolence
- Dry mouth
- Edema
- Blurred vision
- Weight gain
- Thinking abnormal
Pregnancy & Lactation
No adequate and well-controlled studies in pregnant women; small amounts detected in the milk of lactating women; breastfeeding not recommended
Precautions & Warnings
- Angioedema can occur with potential respiratory compromise
- Hypersensitivity reactions warrant discontinuation
- Increased risk of suicidal thoughts or behavior
- Respiratory depression may occur with concomitant CNS depressants
- May cause dizziness and somnolence
- Increased seizure frequency may occur if rapidly discontinued
- Caution with coadministering with thiazolidinedione antidiabetic agents
Use in Special Populations
- Use in children and adolescents: Safety and effectiveness not established for certain conditions
- Pediatric patients for the treatment of partial onset seizures: Safety and effectiveness not established below the age of 1 month
Overdose Effects
Range of symptoms including reduced consciousness, depression/anxiety, seizures, and heart block; no specific antidote
Therapeutic Class
- Adjunct anti-epileptic drugs
- Primary anti-epileptic drugs
Storage Conditions
Keep in a cool & dry place (below 30°C), protected from light & moisture. Keep out of the reach of children
Chemical Structure
- Molecular Formula: C8H17NO2
- Chemical Structure Image: Link to chemical structure image
Common Questions
- What is Lyrinex 50 mg Capsule: An anticonvulsant considered first-line for various conditions
- Improvement in condition: Use until improvement is seen
- Frequency of use: As prescribed by the doctor
- Use with or after food: Should be taken after food in prescribed dosage
- Storage and disposal instructions: Keep in cool dry place in original packaging, out of reach of children and pets
- Uniform working for each disease: Works differently for different diseases
- Duration of use: Depends on the condition; consult the doctor before stopping
- Co-administration with Diazepam: Can be used together
- Potential weight gain: May cause weight gain; consult a dietician if concerned
- Quick Tips:
- Should be taken as per the prescribed dose and duration
- May cause sleepiness and vision changes
- Inform doctor of mood or behavior changes
- Do not stop suddenly without consulting the doctor