Meroxin 1 gm/vial (IV Injection or Infusion)

1 gm vial: ৳ 1,200.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Nipro jmi pharma ltd
Also available as
Meroxin 500 mg injection

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Bactericidal action by interfering with bacterial cell wall synthesis, potent bactericidal activity against a broad spectrum of Gram-positive and Gram-negative, aerobic and anaerobic bacteria.

Dosage

  • Adults:
    • 500 mg to 1 gm by intravenous administration every 8 hours
    • Pneumonia, urinary tract infections, gynaecological infections: 500 mg IV every 8 hours
    • Nosocomial pneumonias, peritonitis: 1 g IV every 8 hours
    • Intra-abdominal infections: 500 mg to 1 gm every 8 hours
    • Cystic fibrosis: Upto 2 gm every 8 hours
    • Meningitis: 2 gm IV every 8 hours
  • Children:
    • 3 months to 12 years: 10 to 40 mg/kg intravenously every 8 hours
    • Intra-abdominal infections: 20 mg/kg every 8 hours
    • Cystic fibrosis (4-18 years): 25-40 mg/kg every 8 hours
    • Meningitis: 40 mg/kg IV every 8 hours
    • Febrile neutropenia: 20 mg/kg every 8 hours

Administration

Intravenous Infusion over approximately 15-30 minutes or as intravenous bolus (5 to 20 ml) over approximately 3-5 minutes

Interaction

  • Probenecid competition for active tubular secretion
  • Reduction in serum valproic acid levels

Contraindications

Hypersensitivity to the product

Side Effects

  • Inflammation
  • Thrombophlebitis
  • Pain at the site of injection
  • Skin reactions like rash, pruritus, urticaria
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

Pregnancy Category B, caution during nursing

Precautions & Warnings

  • Discontinue in case of allergic reaction
  • Careful monitoring in patients with hepatic disease

Use in Special Populations

  • Dosage adjustment in renal impairment
  • Hemodialysis for hemodialysis patients

Overdose Effects

Symptomatic treatment

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

  • Intravenous bolus Administration: Reconstitute with sterile water for injection
  • Intravenous infusion administration: Direct constitution with compatible infusion fluid and further dilution

Storage Conditions

Store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children.

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