Mesagut 400 mg (Tablet (Delayed Release))

Unit Price: ৳ 7.60 (3 x 10: ৳ 228.00)
Strip Price: ৳ 76.00

Medicine Details

Category Details
Generic Mesalazine 5 aminosalicylic acid
Company Aristopharma ltd

Indications

  • Treatment of mild to moderately active Ulcerative Colitis & Crohn’s Disease
  • Maintenance of remission of Ulcerative Colitis
  • Maintenance of remission of Crohn’s disease

Pharmacology

  • Mechanism of action is unknown
  • Appears to have topical rather than systemic action
  • Diminishes inflammation by blocking cyclooxygenase
  • Inhibits prostaglandin production in the colon

Dosage & Administration

  • Adult dosage: Up to 4 gm mesalazine once daily or divided into 2-4 doses for active disease
  • Adult maintenance dosage: 2 gm mesalazine once daily
  • Pediatric dosage: To be determined individually based on age and weight
  • Dosage forms: Granules, sachets
  • Administration: Must not be chewed, should be taken with water or orange juice

Interaction

  • Concurrent use of nephrotoxic agents may increase risk of renal reactions

Contraindications

  • Hypersensitivity to salicylates or any other component of the formulation

Side Effects

  • Headache
  • Nausea
  • Dizziness
  • Asthenia
  • Dyspepsia
  • Vomiting
  • Pruritus

Pregnancy & Lactation

  • Caution in pregnancy
  • Caution in nursing mothers

Precautions & Warnings

  • Risk of prolonged gastric retention in pyloric stenosis patients
  • Caution in patients with renal impairment
  • Monitoring of renal function recommended
  • Reports of hepatic failure in patients with pre-existing liver disease
  • Caution in patients with liver impairment

Use in Special Populations

  • Caution in patients 65 years or older
  • Monitor blood cell counts in elderly patients
  • Caution in patients with decreased renal function
  • Safety and effectiveness not established in pediatric patients

Overdose Effects

  • No specific antidote for Mesalamine overdose
  • Symptomatic and supportive treatment recommended
  • Consideration of delayed-release factor

Therapeutic Class

  • Aminosalicylates

Storage Conditions

  • Store below 30°C
  • Protect from light and moisture
  • Keep out of reach of children

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