Meslamin DR 400 mg (Tablet (Delayed Release))

Unit Price: ৳ 7.58 (5 x 10: ৳ 379.00)
Strip Price: ৳ 75.80

Medicine Details

Category Details
Generic Mesalazine 5 aminosalicylic acid
Company Ibn sina pharmaceuticals ltd

Indications

  • Treatment of mild to moderately active Ulcerative Colitis
  • Treatment of Crohn's Disease
  • Maintenance of remission of Ulcerative Colitis
  • Maintenance of remission of Crohn's disease

Pharmacology

  • Mechanism of action is unknown
  • Appears to be topical rather than systemic
  • Diminishes inflammation by blocking cyclooxygenase
  • Inhibits prostaglandin production in the colon

Dosage & Administration

  • Adult dosage up to 4 gm mesalazine once daily or divided into 2-4 doses for active disease
  • Recommended adult dosage 2 gm mesalazine once daily for maintenance treatment
  • Children dosage starting with 30-50 mg/kg/day in divided doses for active disease
  • Maximum dose for children should not exceed 4 g/day

Interaction

  • Concurrent use of other known nephrotoxic agents may increase the risk of renal reactions

Contraindications

  • Hypersensitivity to salicylates or any other component of the formulation

Side Effects

  • Commonly reported adverse events: headache, nausea, dizziness, asthenia, dyspepsia, vomiting, pruritus

Pregnancy & Lactation

  • Should be given in pregnancy only if the potential benefit justifies the potential risk to the fetus
  • Caution advised when administered to a nursing mother

Precautions & Warnings

  • Patients with pyloric stenosis may have prolonged gastric retention of Mesalamine tablets
  • Renal impairment, including minimal change nephropathy and acute and chronic interstitial nephritis reported
  • Caution should be exercised when using Mesalamine in patients with known renal dysfunction or history of renal disease
  • Hepatic failure reported in patients with pre-existing liver disease who have been administered Mesalamine
  • Caution should be exercised when administering Mesalamine to patients with liver impairment

Use in Special Populations

  • Caution for patients who are 65 years or older
  • Elderly patients are more likely to have decreased renal function
  • Safety and effectiveness not established in pediatric population

Overdose Effects

  • No specific antidote for Mesalamine overdose
  • Treatment should be symptomatic and supportive
  • Consider pH dependent delayed-release factor when treating a suspected overdose

Therapeutic Class

  • Aminosalicylates

Storage Conditions

  • Store below 30°C
  • Protect from light and moisture
  • Keep all medicines out of the reach of children

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