Farmorubicin 2 mg/ml (IV Infusion)

50 mg vial: ৳ 3,118.99

Medicine Details

Category Details
Generic Epirubicin hydrochloride
Company Pfizer

Indications

  • Adjuvant therapy for breast cancer with axillary node tumor involvement

Pharmacology

  • Cytotoxic properties
  • Inhibits DNA and RNA synthesis
  • Distribution into tissues
  • Metabolism by the liver and other organs
  • Excretion through biliary and urinary routes

Dosage & Administration

  • Intravenous infusion
  • Repeated 3 to 4-week cycles
  • Recommended dose of 100 to 120 mg/m²
  • Specific regimens like CEF-120 and FEC-100

Interactions

  • Interaction with cardioactive compounds and cytotoxic drugs
  • Effects of Paclitaxel, Docetaxel, and radiation therapy
  • Hepatic function affect Farmorubicin metabolism

Contraindications

  • Hypersensitivity to Epirubicin or anthracyclines

Side Effects

  • Myelosuppression
  • Cardiotoxicity
  • Alopecia
  • Nausea
  • Vomiting
  • Rash
  • Harmless reddish appearance of urine

Pregnancy & Lactation

  • Pregnancy Category D
  • Unknown excretion in human milk

Precautions & Warnings

  • Storage conditions at refrigerated conditions
  • Baseline assessment before treatment
  • Monitoring for myelosuppression and cardiotoxicity
  • Supportive care for severe complications

Use in Special Populations

  • Dosage adjustments based on toxicities
  • Considerations for bone marrow dysfunction, hepatic impairment, renal impairment
  • Uncertain safety and effectiveness in pediatric patients
  • Monitoring toxicity in elderly female patients

Overdose Effects

  • Supportive treatment in case of overdose
  • Observation for delayed CHF

Therapeutic Class

  • Cytotoxic Chemotherapy

Storage Conditions

  • Store in refrigerator or at 2-8°C
  • Protection from light and children

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