Ifomes 400 mg/4 ml (IV Injection)

400 mg vial: ৳ 190.00 (1 x 2: ৳ 380.00)

Medicine Details

Category Details
Generic Mesna
Company Beacon pharmaceuticals plc

Indications

  • Prophylactic agent for ifosfamide-induced hemorrhagic cystitis
  • Prevention of high dose cyclophosphamide-induced hemorrhagic cystitis

Pharmacology

  • Rapid oxidation to major metabolite Mesna disulfide
  • Rapid elimination by the kidneys
  • Reduction to free thiol compound Mesna
  • Chemical reaction with urotoxic ifosfamide metabolites
  • Detoxification of acrolein and 4-hydroxy-ifosfamide
  • Binding to form nonurotoxic 4-sulfoethylthioifosfamide
  • Binding to other urotoxic metabolites

Dosage & Administration

  • Fractionated dosing schedule
  • Intravenous bolus injections
  • Total daily dose of Mesna is 60% of the ifosfamide dose
  • Preparation of Intravenous Solutions/Stability

Interaction

  • No clinical drug interaction studies conducted with Ifomes

Contraindications

  • Contraindicated in patients with known hypersensitivity to Mesna

Side Effects

  • Colic
  • Depression
  • Diarrhea
  • Fatigue
  • Headache
  • Hypotension
  • Irritability
  • Joint pains
  • Limb pains
  • Nausea
  • Rash
  • Tachycardia
  • Vomiting

Pregnancy & Lactation

  • Pregnancy Category B
  • No adequate and well-controlled studies in pregnant women
  • Excretion in human milk unknown
  • Consideration for nursing mothers

Precautions & Warnings

  • Allergic reactions reported
  • Higher incidence in patients with autoimmune disorders
  • Not effective in preventing or alleviating other adverse reactions
  • Urine examination for hematuria
  • Dosage reduction or discontinuation for severe hematuria
  • Not effective for hematuria due to other pathological conditions
  • Caution in pediatric patients

Overdose Effects

  • No known antidote for Ifomes
  • Lethal oral doses in mice and rats
  • Symptoms of overdose in animals

Therapeutic Class

  • Antidote preparations

Storage Conditions

  • Store in original carton at 20°-25°C
  • Protect from light
  • Keep out of the reach of children

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