Ifomes 400 mg/4 ml (IV Injection)
400 mg vial: ৳ 190.00 (1 x 2: ৳ 380.00)
Medicine Details
Category | Details |
---|---|
Generic | Mesna |
Company | Beacon pharmaceuticals plc |
Indications
- Prophylactic agent for ifosfamide-induced hemorrhagic cystitis
- Prevention of high dose cyclophosphamide-induced hemorrhagic cystitis
Pharmacology
- Rapid oxidation to major metabolite Mesna disulfide
- Rapid elimination by the kidneys
- Reduction to free thiol compound Mesna
- Chemical reaction with urotoxic ifosfamide metabolites
- Detoxification of acrolein and 4-hydroxy-ifosfamide
- Binding to form nonurotoxic 4-sulfoethylthioifosfamide
- Binding to other urotoxic metabolites
Dosage & Administration
- Fractionated dosing schedule
- Intravenous bolus injections
- Total daily dose of Mesna is 60% of the ifosfamide dose
- Preparation of Intravenous Solutions/Stability
Interaction
- No clinical drug interaction studies conducted with Ifomes
Contraindications
- Contraindicated in patients with known hypersensitivity to Mesna
Side Effects
- Colic
- Depression
- Diarrhea
- Fatigue
- Headache
- Hypotension
- Irritability
- Joint pains
- Limb pains
- Nausea
- Rash
- Tachycardia
- Vomiting
Pregnancy & Lactation
- Pregnancy Category B
- No adequate and well-controlled studies in pregnant women
- Excretion in human milk unknown
- Consideration for nursing mothers
Precautions & Warnings
- Allergic reactions reported
- Higher incidence in patients with autoimmune disorders
- Not effective in preventing or alleviating other adverse reactions
- Urine examination for hematuria
- Dosage reduction or discontinuation for severe hematuria
- Not effective for hematuria due to other pathological conditions
- Caution in pediatric patients
Overdose Effects
- No known antidote for Ifomes
- Lethal oral doses in mice and rats
- Symptoms of overdose in animals
Therapeutic Class
- Antidote preparations
Storage Conditions
- Store in original carton at 20°-25°C
- Protect from light
- Keep out of the reach of children