Xevirol 5 mg (Tablet)
Unit Price: ৳ 1,500.00 (1 x 10: ৳ 15,000.00)
Strip Price: ৳ 15,000.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Everolimus |
| Company | Beacon pharmaceuticals plc |
Title
Xevirol Medicine
Categories
- Immunosuppressant
- Cancer Treatment
- Organ Rejection Prophylaxis
- Antineoplastic Agent
Description
Xevirol is a medicine indicated in advanced Hormone Receptor-Positive, HER2-Negative Breast Cancer, Advanced Neuroendocrine Tumors, Advanced Renal Cell Carcinoma, Renal Angiomyolipoma With Tuberous Sclerosis Complex, and Subependymal Giant Cell Astrocytoma. It is also used in combination with ciclosporin for microemulsion & corticosteroids for the prophylaxis of organ rejection in adult patients at low to moderate immunological risk receiving an allogeneic renal or cardiac transplant.
Dimensions
Standard medicine tablet size
Color Options
- White
Functions
- Immunosuppression
- Anticancer
- Preventing organ rejection
Materials
- Active substance - Everolimus
- Excipients
Dosage & Administration
- Initial dose of 0.75 mg bd for general kidney & heart transplant population
- 1 mg bd for hepatic transplant
- Recommended 10 mg dose for breast cancer, neuroendocrine tumors, renal cell carcinoma, and renal angiomyolipoma with TSC
- Swallow whole with water
Mode of Action
- Inhibits proliferation and clonal expansion of T cells
- Forms complex with the cytoplasmic protein FKBP-12
- Inhibits phosphorylation of p70 S6 kinase
- Arrests cell cycle at the G1 stage
Interactions
- CYP3A4 inhibitors & inducers
- CYP2D6 substrates with narrow therapeutic index
- PgP inhibitors
- Rifampicin
- ACE inhibitors
- Grapefruit juice
- Live vaccines
Contraindications
- Hypersensitivity to the active substance or other rapamycin derivatives
- Manifested hypersensitivity reactions
Side Effects
- Stomatitis
- Constipation
- Infections
- Asthenia
- Fatigue
- Cough
- Diarrhea
- Rash
- Anemia
- Nausea
- Anorexia
- Edema
- Dyspnea
- Pyrexia
- Vomiting
- Headache
- Epistaxis
- Decreased lymphocytes
- Increased glucose
- Pneumonitis
- Pruritus
- Dry skin
- Decreased Hgb
- Menstrual irregularities
- Dysgeusia
- Hypertension
- Hemorrhage
- Tachycardia
- CHF
Pregnancy & Lactation
- Pregnancy Category D - Positive evidence of human fetal risk
- Not recommended during lactation
Precautions & Warnings
- Increased risk for angioedema with concomitant ACE inhibitor therapy
- Monitor for clinical symptoms or radiological changes for interstitial lung disease/noninfectious pneumonitis
- Immune-suppressive effects may increase risk for severe or fatal infections
- Common mouth ulcers, stomatitis, and oral mucositis
- May delay wound healing and increase wound-related complications
- Cases of renal failure observed
- Impairment of male fertility
- Avoid use of live vaccines during treatment
- Can cause fetal harm when administered to a pregnant woman
Technical Specifications
- Potent inhibitor of mTOR
- CYP3A4 substrate
Design Elements
- Tablet form
Usability Features
- Swallow whole with water
- Consistent administration with or without food
Warnings
- Distribution into breast milk is unknown
Pregnancy Category
D
Therapeutic Class
Immunosuppressant