Xitabin 500 mg (Tablet)
Unit Price: ৳ 125.00 (5 x 6: ৳ 3,750.00)
Strip Price: ৳ 750.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Capecitabine |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Indications
- Adjuvant Colon Cancer
- Metastatic Colorectal Cancer
- Metastatic Breast Cancer
- Resistance to paclitaxel and anthracycline-containing regimen
Pharmacology
- Prodrug
- Enzymatic conversion to fluorouracil
- Inhibition of DNA synthesis
- Tumour tissue growth inhibition
- Selective tumour activation
- Fluorouracil metabolites
- Cell injury mechanisms
- RNA processing interference
Dosage & Administration
- Monotherapy dosage
- Adjuvant treatment duration
- Combination with docetaxel dosage
- Body weight and height-based dosage calculation
- Administration instructions
- Medical supervision requirement
Interaction
- Anticoagulants monitoring
- Phenytoin levels monitoring
- Leucovorin interaction
- CYP2C9 substrates caution
- Food absorption reduction
Contraindications
- Severe Renal Impairment
- Hypersensitivity
- Leucopenia, neutropenia, thrombocytopenia
- Reactions to fluoropyrimidine therapy
- Complete DPD deficiency
- Pregnancy or breast-feeding
Side Effects
- Abdominal pain
- Rash
- Dry or itchy skin
- Tiredness
- Loss of appetite
- Diarrhea
- Vomiting
- Nausea
- Stomatitis
- Hand-and-foot skin-reaction
- Fever
- Infection
- Chest pain
- Steven-Johnson syndrome
Pregnancy & Lactation
- Pregnancy category D
- Potential fetal harm
- Breastfeeding discontinuation recommendation
Precautions & Warnings
- Coagulopathy monitoring
- Diarrhea management
- Cardiotoxicity risk in coronary artery disease patients
- Risk of severe adverse reactions in DPD deficient patients
- Dehydration and renal failure risk
- Mucocutaneous and dermatologic toxicity
- Hyperbilirubinemia risk
- Hematologic criteria for treatment
Overdose Effects
- Nausea
- Vomiting
- Diarrhea
- Mucositis
- Gastrointestinal irritation
- Bone marrow depression
- Medical management protocols
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Dry place storage
- Temperature limitations
- Light protection
- Child safety