Neotin 150 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Nipa pharmaceuticals ltd |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Post operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal haemorrhage from stress ulcer in seriously ill patient
- Recurrent haemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patient considered to be at risk of acid aspiration particularly obstetric patients
Pharmacology
Ranitidine competitively blocks histamine at H2-receptors of the gastric parietal cells which inhibits gastric acid secretion. It does not affect pepsin secretion, pentagastrin-stimulated intrinsic factor secretion or serum gastrin.
Dosage & Administration
- 150 mg twice daily taken in the morning and evening
- 300 mg as a single daily dose at night for 4 to 8 weeks
- 150 mg twice daily or 300 mg at bedtime for up to 8 weeks
- 150 mg 3 times daily for Zollinger Ellison syndrome
- 150 mg twice daily or 300 mg at bedtime for up to 6 weeks
- 150 mg at night for preventing recurrences
- 2-4 mg/kg twice daily for children
- 50 mg slow intravenous injection, intermittent intravenous infusion at 25 mg per hour, or intramuscular injection of 50 mg every six to eight hours for intravenous use
Interaction
Delayed absorption and increased peak serum concentration with propantheline bromide. Neotin minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam and propranolol. May alter absorption of pH-dependent drugs (e.g. ketoconazole, midazolam, glipizide). May reduce bioavailability with antacids.
Contraindications
Patients hypersensitive to Ranitidine
Side Effects
Altered bowel habit, dizziness, rash, tiredness, reversible confusional states, headache, decreased blood counts, muscle or joint pain
Pregnancy & Lactation
Ranitidine crosses the placenta. No evidence of impaired fertility or harm to the fetus due to Ranitidine. Caution should be exercised when the drug is administered to a nursing mother.
Precautions & Warnings
Neotin should be given in reduced dosage to patients with impaired renal and hepatic function.
Use in Special Populations
Use in elderly patients: The ulcer healing rates have been found similar in patients age 65 and over with those in younger patients. Additionally, there was no difference in the incidence of adverse effects.
Overdose Effects
Neotin is very specific in action and accordingly no particular problems are expected following overdosage with the drug. Symptomatic and supportive therapy should be given as appropriate. If required, the drug may be removed from the plasma by haemodialysis.
Therapeutic Class
H2 receptor antagonist
Reconstitution
- Neotin 50 mg diluted to a concentration ≤2.5 mg/mL with NaCl 0.9% injection or dextrose 5% or 10%, lactated Ringer's, Na bicarbonate 5% solution for slow IV injection and intermittent slow IV infusion
Storage Conditions
Store in a cool and dry place. Protect from light.