Paclitaxel Actavis 6 mg/ml (IV Infusion)

100 mg vial: ৳ 5,200.00

Medicine Details

Category Details
Generic Paclitaxel
Company Bots pvt limited

Indications

  • First line therapy for ovarian carcinoma
  • Adjuvant treatment of node-positive breast cancer
  • First-line therapy of advanced or metastatic breast cancer
  • First line treatment of non-small cell lung carcinoma
  • Second line treatment of AIDS related Kaposi's Sarcoma
  • Treatment of Gastric Carcinoma

Pharmacology

  • Promotes assembly of microtubules
  • Stabilizes microtubules
  • Inhibition of cellular functions
  • Induces abnormal arrays of microtubules

Dosage & Administration

  • Premedication prior to administration
  • Different dosages for different treatments
  • Infusion time and intervals
  • Dose adjustment based on patient tolerance

Interaction

  • Clearance not affected by cimetidine
  • Interaction with cisplatin and doxorubicin
  • Metabolism by cytochrome P450 isoenzymes

Contraindications

  • Severe hypersensitivity reactions
  • Contraindicated during lactation
  • Not to be used in patients with baseline neutrophils or platelets below specified levels
  • Contraindicated in patients with severe hepatic impairment

Side Effects

  • Low blood counts
  • Hair loss
  • Peripheral neuropathy
  • Nausea and vomiting
  • Hypersensitivity reactions
  • Liver problems
  • Edema
  • Darkening of the skin

Pregnancy & Lactation

  • Pregnancy Category D
  • Contraindicated during lactation

Precautions & Warnings

  • Administered under supervision of experienced physician
  • Possible extravasation
  • Hypersensitivity reactions monitoring
  • Bone marrow suppression monitoring
  • Continuous cardiac monitoring in case of conduction abnormalities

Use in Special Populations

  • Dose reduction for severe neutropenia or peripheral neuropathy
  • No recommended use in children below 18 years
  • No dosage alterations recommendation for mild to moderate hepatic impairments

Overdose Effects

  • No known antidote
  • Treatment focuses on primary toxicities
  • May be associated with acute ethanol toxicity in pediatric patients

Reconstitution

  • Dilution prior to infusion
  • Dilution in specified solutions
  • Stability of solutions for up to 27 hours

Storage Conditions

  • Store below 30°C
  • Protect from light
  • Use only freshly prepared solution

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