Paclitaxel Actavis 6 mg/ml (IV Infusion)
100 mg vial: ৳ 5,200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Paclitaxel |
| Company | Bots pvt limited |
Indications
- First line therapy for ovarian carcinoma
- Adjuvant treatment of node-positive breast cancer
- First-line therapy of advanced or metastatic breast cancer
- First line treatment of non-small cell lung carcinoma
- Second line treatment of AIDS related Kaposi's Sarcoma
- Treatment of Gastric Carcinoma
Pharmacology
- Promotes assembly of microtubules
- Stabilizes microtubules
- Inhibition of cellular functions
- Induces abnormal arrays of microtubules
Dosage & Administration
- Premedication prior to administration
- Different dosages for different treatments
- Infusion time and intervals
- Dose adjustment based on patient tolerance
Interaction
- Clearance not affected by cimetidine
- Interaction with cisplatin and doxorubicin
- Metabolism by cytochrome P450 isoenzymes
Contraindications
- Severe hypersensitivity reactions
- Contraindicated during lactation
- Not to be used in patients with baseline neutrophils or platelets below specified levels
- Contraindicated in patients with severe hepatic impairment
Side Effects
- Low blood counts
- Hair loss
- Peripheral neuropathy
- Nausea and vomiting
- Hypersensitivity reactions
- Liver problems
- Edema
- Darkening of the skin
Pregnancy & Lactation
- Pregnancy Category D
- Contraindicated during lactation
Precautions & Warnings
- Administered under supervision of experienced physician
- Possible extravasation
- Hypersensitivity reactions monitoring
- Bone marrow suppression monitoring
- Continuous cardiac monitoring in case of conduction abnormalities
Use in Special Populations
- Dose reduction for severe neutropenia or peripheral neuropathy
- No recommended use in children below 18 years
- No dosage alterations recommendation for mild to moderate hepatic impairments
Overdose Effects
- No known antidote
- Treatment focuses on primary toxicities
- May be associated with acute ethanol toxicity in pediatric patients
Reconstitution
- Dilution prior to infusion
- Dilution in specified solutions
- Stability of solutions for up to 27 hours
Storage Conditions
- Store below 30°C
- Protect from light
- Use only freshly prepared solution