Sindoxplatin 5 mg/ml (IV Infusion)

50 mg vial: ৳ 4,377.00

Medicine Details

Category Details
Generic Oxaliplatin
Company Bots pvt limited

Title

  • Sindoxplatin Infusion

Categories

  • Chemotherapy
  • Oncology
  • Cancer Treatment

Dosage Administration

  • Administer in combination with 5-fluorouracil/folinic acid every 2 weeks
  • Total of 6 months treatment for adjuvant use
  • Specific dosages for Day 1 and Day 2 administration

Pharmacology

  • Undergoes nonenzymatic conversion in physiologic solutions to active derivatives
  • Forms Pt-DNA crosslinks to inhibit DNA replication and transcription
  • Exhibits in vitro and in vivo antiproliferative activity

Interaction

  • No specific cytochrome P-450-based drug interaction studies conducted
  • Increases of 5-fluorouracil plasma concentrations observed with specific doses
  • Clearance may be decreased by coadministration of potentially nephrotoxic compounds

Contraindications

  • Contraindicated in patients with known allergy to oxaliplatin or other platinum compounds

Side Effects

  • Peripheral sensory neuropathy
  • Neutropenia
  • Thrombocytopenia
  • Nausea
  • Increase in transaminases and alkaline phosphatase
  • Diarrhea
  • Emesis
  • Fatigue
  • Stomatitis

Pregnancy & Lactation

  • Pregnancy Category D
  • May cause fetal harm when administered to a pregnant woman
  • No adequate and well-controlled studies in pregnant women

Precautions & Warnings

  • Grade 3/4 hypersensitivity observed in 2-3% of colon cancer patients
  • Neurological toxicity should be carefully monitored
  • Associated with pulmonary fibrosis(<1% of study patients)
  • Reactions related to liver sinusoidal obstruction syndrome reported
  • QT prolongation and ventricular arrhythmias including fatal Torsade de Pointes reported

Overdose Effects

  • No known antidote for overdose
  • Complications include hypersensitivity reaction, myelosuppression, nausea, vomiting, diarrhea, and neurotoxicity
  • Several reported cases of overdose
  • Maximum administered dose is 825 mg

Therapeutic Class

  • Cytotoxic Chemotherapy

Storage Conditions

  • Store in a cool & dry place, protected from light and moisture
  • Keep out of reach of children

Related Brands