Episindan 2 mg/ml (IV Infusion)

10 mg vial: ৳ 915.00

Medicine Details

Category Details
Generic Epirubicin hydrochloride
Company Bots pvt limited

Indications

  • Adjuvant therapy
  • Axillary node tumor involvement
  • Breast cancer

Pharmacology

  • Cytotoxic properties
  • DNA and RNA synthesis inhibition
  • Topoisomerase II cleavage
  • DNA helicase inhibition
  • Cytotoxic free radicals generation
  • Distribution into tissues
  • Plasma protein binding
  • Metabolism by the liver
  • Biliary and urinary excretion
  • Terminal elimination half-life

Dosage & Administration

  • Intravenous infusion
  • 3-to 4-week cycles
  • Dosing regimens
  • Readministration precautions
  • Prophylactic antibiotic therapy
  • Physician's directions

Interaction

  • Cardioactive compounds monitoring
  • Cimetidine interaction
  • Additive toxicity with other cytotoxic drugs
  • Effect on Paclitaxel exposure
  • Effect on Docetaxel exposure
  • Radiation therapy reaction
  • Hepatic function impact

Contraindications

  • Hypersensitivity to Epirubicin
  • Hypersensitivity to anthracyclines or anthracenediones

Side Effects

  • Myelosuppression
  • Cardiotoxicity
  • Alopecia
  • Hyperpyrexia
  • Lethargy
  • Amenorrhoea
  • Nausea
  • Vomiting
  • Diarrhea
  • Fever
  • Rash
  • Anorexia
  • Reddish appearance of urine

Pregnancy & Lactation

  • Pregnancy Category D
  • Use justification
  • Excretion in human milk

Precautions & Warnings

  • Refrigerated storage impact
  • Formation of gelled product
  • Visual inspection prior to administration
  • Handling and disposal procedures
  • Experienced physician supervision
  • Baseline assessment
  • Blood counts monitoring
  • Cardiac function monitoring
  • Supportive care
  • Cardiotoxicity monitoring

Use in Special Populations

  • Dosage adjustments based on toxicities
  • Bone marrow dysfunction consideration
  • Hepatic and renal impairment recommendations
  • Pediatric use considerations
  • Geriatric use precautions

Overdose Effects

  • Supportive treatment
  • Observation for CHF signs
  • Supportive therapy provision

Therapeutic Class

  • Cytotoxic Chemotherapy

Storage Conditions

  • Refrigerator storage
  • Protect from light
  • Keep out of the reach of children

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