Episindan 2 mg/ml (IV Infusion)
10 mg vial: ৳ 915.00
Medicine Details
Category | Details |
---|---|
Generic | Epirubicin hydrochloride |
Company | Bots pvt limited |
Indications
- Adjuvant therapy
- Axillary node tumor involvement
- Breast cancer
Pharmacology
- Cytotoxic properties
- DNA and RNA synthesis inhibition
- Topoisomerase II cleavage
- DNA helicase inhibition
- Cytotoxic free radicals generation
- Distribution into tissues
- Plasma protein binding
- Metabolism by the liver
- Biliary and urinary excretion
- Terminal elimination half-life
Dosage & Administration
- Intravenous infusion
- 3-to 4-week cycles
- Dosing regimens
- Readministration precautions
- Prophylactic antibiotic therapy
- Physician's directions
Interaction
- Cardioactive compounds monitoring
- Cimetidine interaction
- Additive toxicity with other cytotoxic drugs
- Effect on Paclitaxel exposure
- Effect on Docetaxel exposure
- Radiation therapy reaction
- Hepatic function impact
Contraindications
- Hypersensitivity to Epirubicin
- Hypersensitivity to anthracyclines or anthracenediones
Side Effects
- Myelosuppression
- Cardiotoxicity
- Alopecia
- Hyperpyrexia
- Lethargy
- Amenorrhoea
- Nausea
- Vomiting
- Diarrhea
- Fever
- Rash
- Anorexia
- Reddish appearance of urine
Pregnancy & Lactation
- Pregnancy Category D
- Use justification
- Excretion in human milk
Precautions & Warnings
- Refrigerated storage impact
- Formation of gelled product
- Visual inspection prior to administration
- Handling and disposal procedures
- Experienced physician supervision
- Baseline assessment
- Blood counts monitoring
- Cardiac function monitoring
- Supportive care
- Cardiotoxicity monitoring
Use in Special Populations
- Dosage adjustments based on toxicities
- Bone marrow dysfunction consideration
- Hepatic and renal impairment recommendations
- Pediatric use considerations
- Geriatric use precautions
Overdose Effects
- Supportive treatment
- Observation for CHF signs
- Supportive therapy provision
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Refrigerator storage
- Protect from light
- Keep out of the reach of children