Zerlinda 4 mg/5 ml (IV Infusion)
4 mg vial: ৳ 7,800.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Zoledronic acid for hypercalcemia |
| Company | Bots pvt limited |
Product Title
- Zerlinda
Categories
- Medicine
- Health
- Therapeutic
Description
- Zoledronic acid medication indicated for hypercalcemia of malignancy, bone metastases, osteoporosis, multiple myeloma, Paget's disease, and prophylaxis of postmenopausal osteoporosis.
- Belongs to the class of nitrogen-containing bisphosphonates, acts primarily on bone, inhibitor of osteoclast-mediated bone resorption, possesses anti-tumour, anti-angiogenic, and pain-relief activities.
Indications
- Hypercalcaemia of malignancy
- Bone metastases associated with solid tumours
- Osteolytic lesions associated with multiple myeloma
- Corticosteroid-induced osteoporosis
- Increase bone mass in men with osteoporosis
- Osteoporosis in postmenopausal women
- Paget's disease of bone
- Prophylaxis of postmenopausal osteoporosis
Pharmacology
- Belongs to the class of nitrogen-containing bisphosphonates
- Acts primarily on bone
- Inhibitor of osteoclast-mediated bone resorption
- Rapidly distributed to bone
- Main molecular target is the enzyme farnesyl pyrophosphate synthase
- Possesses anti-tumour, anti-angiogenic, and pain-relief activities
- No accumulation in plasma after multiple doses
- Not metabolized, excreted unchanged via the kidney
Dosage
- Maximum recommended dose for hypercalcemia of malignancy is 4 mg as a single-dose intravenous infusion
- Recommended dose for multiple myeloma and bone metastases of solid tumors is 4 mg infused every 3-4 weeks
- Patients should be administered an oral calcium supplement of 500 mg and 400 IU of Vitamin-D daily
Administration
- Prior to administration, the required amount of concentrate from one vial must be further diluted with 100 ml of calcium-free infusion solution
- Duration of infusion must not be less than 15 minutes
- Infusion solution should be used as soon as possible after preparation
- Must not be mixed with calcium or other divalent cation-containing infusion solutions
Interaction
- Administered concomitantly with commonly used anticancer agents, diuretics, antibiotics, and analgesics without interactions
- Caution advised when administered with aminoglycosides, thalidomide, or loop diuretics
- Concomitant use with potentially nephrotoxic drugs should be approached with caution
Contraindications
- Hypersensitivity to the active substance, excipients, or any bisphosphonates
- Severe renal impairment (Creatinine clearance <30 ml/min)
- Pregnancy and lactation
Side Effects
- Headache
- Nausea
- Anorexia
- Fatigue
- Osteonecrosis of jaw
- Anemia
- Bone pain
- Constipation
- Fever
- Vomiting
- Flu-like syndrome
- Hypocalcemia
- Myalgia
- Arthralgia
- Hypophosphataemia
Pregnancy & Lactation
- Contraindicated during pregnancy and in breast-feeding women
- Not recommended for use in children and adolescents below 18 years of age
Precautions & Warnings
- Patients must be appropriately hydrated prior to administration
- Hydration is especially important in the elderly and for patients receiving diuretic therapy
- Careful monitoring of calcium, phosphate, magnesium, and potassium levels is necessary
- Renal function should be monitored carefully
Use in Special Populations
- Use not recommended in patients with severe renal impairment (Creatinine clearance <30 ml/min)
- No dose adjustment necessary in patients with creatinine clearance >60 ml/min
- Dose adjustment based on creatinine clearance for patients with impaired renal function
Overdose Effects
- Limited clinical experience with acute overdosage
- May cause hypocalcemia, hypophosphatemia, and hypomagnesemia
- Correction may require intravenous administration of calcium gluconate, potassium or sodium phosphate, and magnesium sulfate
Therapeutic Class
- Bisphosphonate preparations
Reconstitution
- Dilute the required amount in 100 mL of NaCl 0.9% or dextrose 5%
Storage Conditions
- Store below 30°C prior to opening
- Protect from moisture and light
- Keep out of the reach and sight of children