Paxel 6 mg/ml (IV Infusion)

30 mg vial: ৳ 2,080.00

Medicine Details

Category Details
Generic Paclitaxel
Company Healthcare pharmaceuticals ltd

Indications

  • Treatment of advanced carcinoma of the ovary
  • Adjuvant treatment of node-positive breast cancer
  • Treatment of breast cancer after failure of combination chemotherapy
  • First-line therapy of advanced or metastatic breast cancer
  • Treatment of non-small cell lung cancer
  • Second-line treatment of AIDS related Kaposi's Sarcoma
  • Treatment of Gastric Carcinoma

Pharmacology

  • Promotes assembly of microtubules
  • Stabilizes microtubules
  • Inhibits normal dynamic reorganization of the microtubule network
  • Induces abnormal arrays of microtubules
  • Causes multipole asters of microtubules during mitosis
  • Plasma concentrations decline in a biphasic manner

Dosage & Administration

  • Premedication required before administration
  • Different dosages and durations for various cancer treatments
  • Recommended dose adjustments based on individual patient tolerance

Interaction

  • Cimetidine does not affect Paxel clearance
  • Cisplatin treatment affects Paxel clearance
  • Sequence effects observed with Paxel and doxorubicin combination use
  • Metabolism catalyzed in part by cytochrome P450 isoenzymes
  • Caution required when administering Paxel concomitantly with certain medicines

Contraindications

  • Severe hypersensitivity reactions to paclitaxel
  • Contraindicated during lactation
  • Not to be used in patients with specific baseline neutrophil and platelet counts
  • Contraindicated in patients with severe hepatic impairment
  • Contraindicated in AIDS patients with concurrent serious, uncontrolled infections

Side Effects

  • Low blood counts
  • Increased risk for infection, anemia, and/or bleeding
  • Hair loss
  • Arthralgias and myalgias
  • Peripheral neuropathy
  • Mild to moderate nausea and vomiting
  • Diarrhea
  • Mouth sores
  • Hypersensitivity reactions
  • Facial flushing
  • Chills
  • Shortness of breath
  • Hives
  • Edema
  • Liver problems
  • Low blood pressure
  • Darkening of the skin

Pregnancy & Lactation

Pregnancy Category D

Precautions & Warnings

  • Should be administered under the supervision of an experienced physician
  • Significant hypersensitivity reactions may occur
  • Close monitoring of infusion site for possible infiltration required
  • Severe bone marrow suppression, primarily neutropenia, is the dose-limiting toxicity
  • Severe cardiac conduction abnormalities reported rarely

Use in Special Populations

  • Dose adjustment for patients with severe neutropenia or severe peripheral neuropathy
  • Usage not recommended in children below 18 years due to lack of data on safety and efficacy

Overdose Effects

No known antidote for Paxel overdose

Reconstitution

Paxel Injection must be diluted prior to infusion

Storage Conditions

Store below 30°C, protect from light, and use only freshly prepared solution

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