Cisplat 1 mg/ml (IV Infusion)
10 mg vial: ৳ 300.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cisplatin |
| Company | Healthcare pharmaceuticals ltd |
Indications
- Metastatic Testicular Tumors
- Metastatic Ovarian Tumors
- Advanced Bladder Cancer
- Small Cell Lung Carcinoma
Pharmacology
- Platinum compound
- Inhibits DNA synthesis
- Inhibits protein and RNA synthesis
- Produces intra-and interstrand cross links
Dosage & Administration
- Administered by slow intravenous infusion
- Should not be given by rapid intravenous injection
- Dose varies for different types of tumors
- Specific dosages for metastatic testicular and ovarian tumors, advanced bladder cancer, and non small cell lung carcinoma
Interaction
- Used in combination with other antineoplastic drugs
- Potential drug interactions with nephrotoxic, ototoxic, renally excreted, anticonvulsant, and antigout drugs
Contraindications
- Pre-existing renal impairment
- History of hypersensitivity to Cisplatin or Platinum containing compounds
- Myelosuppressed patients
- Patients with hearing impairment
Side Effects
- Severe nausea and vomiting
- Electrolyte disturbances
- Renal tubular dysfunction
- Hypomagnesemia, hypocalcemia, hypokalemia
Pregnancy & Lactation
- Pregnancy Category D
- No adequate and well controlled studies in pregnant women
- Found in human milk
- Excretion in human milk unknown
Precautions & Warnings
- Cumulative nephrotoxicity
- Renal function evaluation
- Peripheral blood counts monitoring
- Audiometry for ototoxicity
- Neurotoxicity monitoring
- Severe nausea and vomiting management
- Potential carcinogenicity
- Dental precautions
Overdose Effects
- Kidney failure
- Liver failure
- Deafness
- Ocular toxicity
- Myelosuppression
- Intractable nausea and vomiting
- Neuritis
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Store at 25°C
- Do not refrigerate
- Protect from light
- Keep out of the reach of children