Xelobine 500 mg (Tablet)
Unit Price: ৳ 138.00 (3 x 10: ৳ 4,140.00)
Strip Price: ৳ 1,380.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Capecitabine |
| Company | Healthcare pharmaceuticals ltd |
Indications
- Adjuvant Colon Cancer
- Metastatic Colorectal Cancer
- First-line monotherapy
- Metastatic Breast Cancer
- Resistance to paclitaxel and anthracycline-containing regimen
Pharmacology
- Orally-administered
- Chemotherapeutic agent
- Prodrug conversion to fluorouracil
- Inhibition of DNA synthesis
- Slow growth of tumor tissue
- Tumor-activated cytotoxic moiety
- Metabolized to active components
- Cell injury mechanisms
Dosage & Administration
- Monotherapy at 1250 mg/m2 twice daily
- Adjuvant treatment for 6 months
- Combination with docetaxel
- Individualized dosage adjustment
- Specific dosage for body weight and height
- Oral administration with meals and water
- Prescribed by experienced doctor
Interaction
- Anticoagulants monitoring
- Phenytoin levels monitoring
- Enhanced concentration with leucovorin
- CYP2C9 substrates caution
- Reduced absorption with food
Contraindications
- Severe Renal Impairment
- Hypersensitivity
- Leucopenia, neutropenia, thrombocytopenia
- Severe reactions to fluoropyrimidine therapy
- Complete DPD deficiency
- Pregnancy or breast-feeding
Side Effects
- Abdominal pain
- Rash
- Dry or itchy skin
- Tiredness
- Loss of appetite
- Diarrhea
- Vomiting
- Nausea
- Stomatitis
- Hand-and-foot skin-reaction
- Fever
- Infection
- Chest pain
- Steven-Johnson syndrome
Pregnancy & Lactation
- Pregnancy category D
- Fetal harm potential
- Impact on breast milk unknown
- Discontinuation of breast-feeding
Precautions & Warnings
- Coagulopathy monitoring
- Diarrhea management
- Cardiotoxicity risk
- Severe or fatal adverse reactions in low DPD activity
- Dehydration and renal failure risk
- Mucocutaneous and dermatologic toxicity
- Hyperbilirubinemia risk
- Hematologic risk
Overdose Effects
- Nausea
- Vomiting
- Diarrhea
- Mucositis
- Gastrointestinal irritation and bleeding
- Bone marrow depression
- Therapeutic and supportive interventions
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Dry place
- Store below 30°C
- Protect from light
- Keep out of reach of children