Initer 5000 IU (IV/SC Injection)

5000 IU pre-filled syringe: ৳ 2,557.71

Medicine Details

Category Details
Generic Erythropoietin alfa
Company Healthcare pharmaceuticals ltd
Also available as
Initer 2000 iu injection Initer 3000 iu injection Initer 10000 iu injection

Indications

  • Treatment of anemia in Chronic Kidney Disease (CKD) patients on dialysis and not on dialysis
  • Treatment of anemia in HIV-infected patients on Zidovudine
  • Reduction of allogeneic RBC transfusions in patients undergoing elective, noncardiac, nonvascular surgery
  • Prevention of anemia of prematurity in infants with a birth weight of 750 to 1500 gm and gestational age of less than 34 weeks

Description

Recombinant human erythropoietin (EPO) expressed in Chinese hamster ovary cells with a 165 amino acid sequence identical to human urinary EPO

Dosage

  • Evaluation of Iron Stores and Nutritional Factors before and during treatment
  • Monitoring hemoglobin levels at least weekly until stable, then at least monthly
  • Dose adjustments based on hemoglobin rate of rise, rate of decline, and ESA responsiveness
  • Different starting doses and dose adjustments for CKD patients on dialysis and not on dialysis, Zidovudine-treated HIV-infected Patients, and Cancer Patients on Chemotherapy

Administration

  • Do not shake or freeze
  • Visual inspection for particulate matter and discoloration before administration
  • Protection from light
  • Discard unused portions

Interaction

Potentiation by therapeutic administration of a haematinic agent like ferrous sulphate when a deficiency state exists

Contraindications

  • Uncontrolled hypertension
  • Serious allergic reactions to Erythropoietin alfa
  • Pure Red Cell Aplasia (PRCA) following treatment with any erythropoietin

Side Effects

  • Hypertension, arthralgia, muscle spasm, pyrexia, dizziness, medical device malfunction, vascular occlusion, and upper respiratory tract infection in CKD patients
  • Pyrexia, cough, rash, and injection site irritation in Zidovudine-treated HIV-infected Patients
  • Nausea, vomiting, myalgia, arthralgia, stomatitis, cough, weight decrease, leukopenia, bone pain, rash, hyperglycemia, headache, depression, dysphagia, hypokalemia, and thrombosis in Cancer Patients on Chemotherapy
  • Nausea, vomiting, pruritus, headache, injection site pain, chills, deep vein thrombosis, cough, and hypertension in Surgery Patients
  • Fall in serum ferritin values in premature infants

Pregnancy & Lactation

  • Caution in pregnancy due to potential risks
  • Caution in nursing women, decision is based on benefit to the child and woman

Overdose Effects

Manage with discontinuation or reduction of dosage and/or with phlebotomy, as clinically indicated; Severe hypertension observed in overdose cases

Therapeutic Class

Drugs for Haemolytic Hypoplastic & Renal Anemia

Storage Conditions

Store at 2°C to 8°C, protect from freezing and light

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