Normacid 50 mg/2 ml (IM/IV Injection)
2 ml ampoule: ৳ 6.02 (10's pack: ৳ 60.20)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Kemiko pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Ulcer associated with non-steroidal anti-inflammatory agent
- Post operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal hemorrhage from stress ulcer in seriously ill patient
- Recurrent hemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patient considered to be at risk of acid aspiration
- Obstetric patients
Pharmacology
- Competitively blocks histamine at H2-receptors of the gastric parietal cells
- Inhibits gastric acid secretion
- Does not affect pepsin secretion
- Pentagastrin-stimulated intrinsic factor secretion
- Serum gastrin
Dosage & Administration
- Usual dosage of 150 mg twice daily for 4 to 8 weeks
- Usual dosage of 300 mg as a single daily dose at night for 4 to 8 weeks
- Dosage for reflux oesophagitis
- Dosage for Zollinger Ellison syndrome
- Dosage for episodic dyspepsia
- Maintenance dosage
- Dosage for children with peptic ulcer
- Ranitidine injection dosage
Interaction
- Delayed absorption and increased peak serum concentration with propantheline bromide
- Minimally inhibits hepatic metabolism of certain drugs
- May alter absorption of pH-dependent drugs
- May reduce bioavailability with antacids
Contraindications
- Patients hypersensitive to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Crosses the placenta
- Excreted in human breast milk
- Caution should be exercised when administered to a nursing mother
Precautions & Warnings
- Should be given in reduced dosage to patients with impaired renal and hepatic function
Use in Special Populations
- Use in elderly patients
Overdose Effects
- No particular problems expected following overdosage
- Symptomatic and supportive therapy should be given
- Drug may be removed from the plasma by hemodialysis
Therapeutic Class
- H2 receptor antagonist
Reconstitution
- Instructions for slow IV injection
- Intermittent slow IV infusion
- Continuous IV infusion
- Dilution for patients with hypersecretory conditions
Storage Conditions
- Cool and dry place
- Protection from light