5 FU PhaRes 25 mg/ml (IV Injection or Infusion)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluorouracil |
| Company | Pharma resources |
Indications
- Carcinoma of the colon or rectum
- Carcinoma of the stomach and exocrine pancreas
- Carcinoma of the liver
- Carcinoma of the breast
- Carcinoma of the bladder
- Carcinoma of the lung
- Epithelial ovarian carcinoma
- Cervical carcinoma
Pharmacology
Fluorouracil is converted into the active 5-fluorodeoxyuridine monophosphate (FdUMP) by a variety of different metabolic pathways. The drug works by inhibiting the enzyme thymidylate kinase which results in reduced formation of thymidine and thus of DNA.
Dosage & Administration
- Intravenous delivery by rapid bolus injection or slow infusion
- Palliative management
- Poor risk patients and those who are not in an adequate nutritional state
- Maintenance therapy
- Usual adult dose for cervical cancer
- Usual pediatric dose for malignant disease
- Intra-arterial infusion
- Combination with radiation
- Combination with other anticancer drugs
Interaction
Pre-treatment with cimetidine for 4 weeks led to increased plasma concentrations of 5 FU PhaRes following intravenous and oral administration in 6 patients.
Contraindications
- Severely debilitated patients
- Patients with bone marrow suppression due to radiotherapy or chemotherapy
- Pregnant or breastfeeding women
- Patients without malignant illnesses
Side Effects
- Potentially life-threatening effects
- Cardiac effects
- Hematological effects
- Neurological effects
- Allergic reactions
- Decreased bone marrow function
- Hand-foot syndrome
- Severe vomiting and diarrhea
- Conjunctivitis
- Temporary hair loss
Pregnancy & Lactation
Fluorouracil is contraindicated throughout pregnancy and mothers should not nurse while receiving this drug.
Precautions & Warnings
5-5 FU PhaRes is a highly toxic drug with a narrow margin of safety. Patients should be carefully supervised, and treatment should be discontinued promptly when signs of toxicity appear.
Use in Special Populations
- Neonates
- Children
- The elderly
Overdose Effects
Cases of deliberate overdose are unknown but excessive toxicity because of the hematological effects. Supportive care is the main treatment for overdose.
Reconstitution
5-5 FU PhaRes is a cytotoxic anticancer drug and should be handled with caution. Special, trained personnel should reconstitute the drug.
Storage Conditions
Store the vial in original carton not exceeding 25℃. Do not refrigerate. Protect from light.